Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review).
Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review).
复制标题
CCN家族蛋白在肿瘤发生和癌症转移中的新兴作用（综述）。
DOI：
10.3892/ijmm.2015.2390
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发表时间：
2015-12
影响因子：
5.4
通讯作者：
Jiang WG
中科院分区：
文献类型：
--
作者：
Li J;Ye L;Owen S;Weeks HP;Zhang Z;Jiang WG
CCN蛋白家族包括成员CCN 1、CCN 2、CCN 3、CCN 4、CCN 5和CCN 6。它们共有四个进化上保守的功能结构域，通常与各种细胞因子相互作用，通过多种信号通路引发不同的生物学功能，包括细胞增殖、粘附、侵袭、迁移、胚胎发育、血管生成、伤口愈合、纤维化和炎症。在过去的二十年中，CCN蛋白（CCN）的新兴功能已在各种类型的癌症中被确定。在多种恶性肿瘤中已经观察到CCN的干扰表达。某些CCN的异常表达与疾病进展和不良预后相关。深入了解CCN介导的调控的详细机制可能有助于了解它们在肿瘤发生和癌症转移中的作用和功能。本文简要介绍了CCN的功能，特别是在癌症中的作用。
The CCN family of proteins comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6. They share four evolutionarily conserved functional domains, and usually interact with various cytokines to elicit different biological functions including cell proliferation, adhesion, invasion, migration, embryonic development, angiogenesis, wound healing, fibrosis and inflammation through a variety of signalling pathways. In the past two decades, emerging functions for the CCN proteins (CCNs) have been identified in various types of cancer. Perturbed expression of CCNs has been observed in a variety of malignancies. The aberrant expression of certain CCNs is associated with disease progression and poor prognosis. Insight into the detailed mechanisms involved in CCN-mediated regulation may be useful in understanding their roles and functions in tumorigenesis and cancer metastasis. In this review, we briefly introduced the functions of CCNs, especially in cancer.