Quality of life characteristics inpatients with cervical cancer
Quality of life characteristics inpatients with cervical cancer
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DOI：
10.1016/j.ejca.2012.05.011
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发表时间：
2012-11-01
影响因子：
8.4
通讯作者：
Greimel, Elfriede
中科院分区：
文献类型：
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作者：
Bjelic-Radisic, Vesna;Jensen, Pernille T.;Greimel, Elfriede
目标：全世界每年约有 500,000 名女性被诊断患有宫颈癌。对于许多患者来说，诊断时的年龄和该疾病的良好预后意味着很长的寿命，并且可以承受各种治疗方案的副作用和后遗症。本研究调查了绝经状态、治疗状态和治疗方式对宫颈癌治疗期间和治疗后不同生活质量（QoL）领域的影响程度。方法：根据绝经状态、治疗状态和治疗方式对欧洲癌症研究与治疗组织（EORTC）生活质量组宫颈癌模块验证研究中纳入的来自14个国家的346名宫颈癌患者的生活质量数据进行分析。使用 EORTC 生活质量问卷 (QLQ)-C30 和 QLQ-CX24 模块评估 QOL。使用描述性统计和协方差分析进行统计分析。结果：积极治疗对 13 个不同的生活质量领域具有最强的负面影响：身体、角色、情绪、认知、社会功能、整体健康/生活质量、疲劳、恶心和呕吐、疼痛、食欲不振、便秘、症状体验和性享受。单独照射+/-其他治疗与大多数腹泻症状相关。年龄对性活动的负面影响最大，对性担忧的正面影响最强。结论：我们的研究结果显示，根据绝经状态和治疗方式，宫颈癌患者会出现不同的副作用，对生活质量的影响也不同。应告知患者治疗可能对生活质量产生负面影响的可能性。 (C) 2012 Elsevier Ltd. 保留所有权利。
Aim: Annually about 500,000 women worldwide are diagnosed with cervical cancer. For many patients, young age at the time of diagnosis and a good prognosis regarding the disease imply a long life with the side-effects and sequels of various treatment options. The present study investigated the extent to which different quality of life (QoL) domains in patients during and after treatment for cervical cancer are affected according to menopausal status, treatment status and treatment modality.Methods: QoL data from 346 cervical cancer patients from 14 countries who were included in a cervical cancer module validation study of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of life Group were analysed according to menopausal status, treatment status and treatment modality. QOL was assessed using the EORTC Quality of life Questionnaire (QLQ)-C30 and the QLQ-CX24 module. Statistical analyses were performed using descriptive statistics and analysis of covariance.Results: Active treatment had the strongest negative impact on 13 different QoL domains: physical, role, emotional, cognitive, social functioning, global health/QoL, fatigue, nausea and emesis, pain, appetite loss, constipation, symptom experience and sexual enjoyment. Irradiation alone +/- other therapy was associated with most symptoms of diarrhoea. Age had the most negative impact on sexual activity and the strongest positive effect on sexual worry.Conclusion: Our results revealed that patients with cervical carcinoma had different side-effects with different impacts on QOL depending on the menopausal status and therapy modalities. Patients should be informed about the possibility that therapy may have a negative impact on QoL. (C) 2012 Elsevier Ltd. All rights reserved.