The prevalence and incidence of neurocognitive impairment in the HAART era
The prevalence and incidence of neurocognitive impairment in the HAART era
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DOI：
10.1097/qad.0b013e32828e4e27
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发表时间：
2007-09-12
期刊：
影响因子：
3.8
通讯作者：
Ellis, Ron J.
中科院分区：
文献类型：
--
作者：
Robertson, Kevin R.;Smurzynski, Marlene;Ellis, Ron J.
目的：高效抗逆转录病毒疗法（HAART）抑制HIV病毒复制，恢复免疫功能。HAART对神经系统疾病的影响还不太清楚。本研究的目的是评估作为AIDS临床试验一部分的HAART患者神经认知功能障碍的患病率和发病率。设计：一项前瞻性队列研究，HIV阳性患者参加了随机抗逆转录病毒试验，AIDS临床试验组（ACTG）纵向连锁随机试验（ALLRT）研究。我们研究了1160名参加ALLRT研究的受试者的基线和人口统计学特征与神经认知障碍之间的关系。结果：免疫抑制史（CD4细胞计数最低值
Objectives: HAART suppresses HIV viral replication and restores immune function. The effects of HAART on neurological disease are less well understood. The aim of this study was to assess the prevalence and incidence of neurocognitive impairment in individuals who initiated HAART as part of an AIDS clinical trial.Design: A prospective cohort study of HIV-positive patients enrolled in randomized antiretroviral trials, the AIDS Clinical Trials Group (ACTG) Longitudinal Linked Randomized Trials (ALLRT) study.Methods: We examined the association between baseline and demographic characteristics and neurocognitive impairment among 1160 subjects enrolled in the ALLRT study. Results: A history of immunosuppression (nadir CD4 cell count