Identification of Genetic and Non-genetic Risk Factors for Nasopharyngeal Carcinoma in a Southeast Asian Population
Identification of Genetic and Non-genetic Risk Factors for Nasopharyngeal Carcinoma in a Southeast Asian Population
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DOI：
10.7314/apjcp.2012.13.12.6005
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Ler, Lian Wee
中科院分区：
文献类型：
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作者：
Hashim, Nikman Adli Nor;Ramzi, Nurul Hanis;Ler, Lian Wee
背景：鼻咽癌（NPC）是中国南方和东南亚人群的地方病。癌症的地理和种族聚集是由于遗传，环境和生活方式的风险因素。这项病例对照研究旨在确定或确认在流行国家之一马来西亚的NPC遗传和非遗传危险因素。材料与方法：选择了一组768个与各种癌症相关的单核苷酸多态性（SNPs）和已知的NPC非遗传危险因素，并在病例对照研究中分析了它们与NPC的关联。结果如下：统计分析确定了40个SNPs与我们人群中的NPC风险相关，包括5个先前由全基因组关联研究（GWAS）和其他病例对照研究记录的SNPs;其余35个SNPs与NPC的关联是新的。此外，与以前的研究一致，暴露于职业危害，过度食用盐腌食品，红肉以及水果和蔬菜摄入量低也与NPC风险有关。结论：简而言之，这项研究证实和/或确定了与东南亚人群中NPC易感性相关的遗传，环境和饮食风险因素。
Background: Nasopharyngeal carcinoma (NPC) is endemic in Southern Chinese and Southeast Asian populations. Geographical and ethnic clustering of the cancer is due to genetic, environmental, and lifestyle risk factors. This case-control study aimed to identify or confirm both genetic and non-genetic risk factors for NPC in one of the endemic countries, Malaysia. Materials and Methods: A panel of 768 single-nucleotide polymorphisms (SNPs) previously associated with various cancers and known non-genetic risk factors for NPC were selected and analyzed for their associations with NPC in a case-control study. Results: Statistical analysis identified 40 SNPs associated with NPC risk in our population, including 5 documented previously by genome-wide association studies (GWAS) and other case-control studies; the associations of the remaining 35 SNPs with NPC were novel. In addition, consistent with previous studies, exposure to occupational hazards, overconsumption of salt-cured foods, red meat, as well as low intake of fruits and vegetables were also associated with NPC risk. Conclusions: In short, this study confirmed and/or identified genetic, environmental and dietary risk factors associated with NPC susceptibility in a Southeast Asian population.