The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death - A population-based study of 13000 men and women with 20 years of follow-up
The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death - A population-based study of 13000 men and women with 20 years of follow-up
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DOI：
10.1001/archinte.164.13.1422
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发表时间：
2004-07-12
影响因子：
--
通讯作者：
Vestergaard, H
中科院分区：
文献类型：
--
作者：
Almdal, T;Scharling, H;Vestergaard, H
背景资料：流行病学研究已经报道，2型糖尿病（DM）患者的心血管疾病的死亡率和发病率增加，与其他危险因素无关。然而，这些研究中的大多数都是在选定的患者组中进行的。本研究的目的是前瞻性地评估2型糖尿病对心血管疾病的发病率和死亡率的影响，在cardiovascular population.Methods：共13 105例受试者从哥本哈根市心脏研究进行了前瞻性随访20年。对2型糖尿病患者与健康对照组相比，缺血性心脏病、急性心肌梗死或卒中的首次、事件、入院或死亡的校正相对风险以及总死亡率进行了估计。女性首次、发生和入院心肌梗死的相对风险增加1.5- 4.5倍，男性增加1.5- 2倍，在性别之间有显著差异。女性首次卒中、卒中事件和卒中入院的相对风险增加2- 6.5倍，男性增加1.5- 2倍，性别间差异显著。在女性和男性的相对死亡风险增加1.5至2倍。结论：在2型糖尿病患者中，发生心肌梗死或中风的风险增加2至3倍，死亡的风险增加2倍，独立于其他已知的心血管疾病的危险因素。
Background: Epidemiological studies have reported that patients with type 2 diabetes mellitus (DM) have increased mortality and morbidity from cardiovascular diseases, independent of other risk factors. However, most of these studies have been performed in selected patient groups. The purpose of the present study was prospectively to assess the impact of type 2 DM on cardiovascular morbidity and mortality in an unselected population.Methods: A total of 13 105 subjects from the Copenhagen City Heart Study were followed up prospectively for 20 years. Adjusted relative risks of first, incident, admission for, or death from ischemic heart disease, acute myocardial infarction, or stroke, as well as total mortality in persons with type 2 DM compared with healthy controls, were estimated.Results: The relative risk of first, incident, and admission for myocardial infarction was increased 1.5- to 4.5-fold in women and 1.5- to 2-fold in men, with a significant difference between sexes. The relative risk of first, incident, and admission for stroke was increased 2- to 6.5-fold in women and 1.5- to 2-fold in men, with a significant difference between sexes. In both women and men the relative risk of death was increased 1.5 to 2 times.Conclusions: In persons with type 2 DM, the risk of having an incident myocardial infarction or stroke is increased 2- to 3-fold and the risk of death is increased 2-fold, independent of other known risk factors for cardiovascular diseases.