New factors controlling the balance between osteoblastogenesis and adipogenesis
New factors controlling the balance between osteoblastogenesis and adipogenesis
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DOI：
10.1016/j.bone.2011.06.030
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发表时间：
2012-02-01
期刊：
影响因子：
4.1
通讯作者：
Kassem, Moustapha
中科院分区：
文献类型：
--
作者：
Abdallah, Basem M.;Kassem, Moustapha
大多数与骨丢失相关的疾病，包括衰老，都伴随着骨髓肥胖的增加，这可能是由于骨髓基质（骨骼）干细胞（MSC）中成骨细胞和脂肪细胞分化之间的平衡发生了变化。为了研究骨髓中成骨细胞生成和脂肪生成之间的关系，我们对多能MSC以及前成骨细胞和前脂肪细胞群的细胞模型进行了表征。使用这些模型，我们确定了两个分泌因子在骨髓微环境：分泌卷曲相关蛋白1（sFRP-1）和delta-likel（前脂肪细胞因子1）（Dlk 1/Pref-1）。两者都对成骨细胞和脂肪形成发挥调节作用。我们的研究提出了一种MSC谱系命运决定模型，该模型通过骨髓微环境中的分泌因子进行调节，这些因子除了控制多能MSC的分化选择外，还介导谱系定向细胞群之间的串扰。这篇文章是特刊的一部分，题为：骨，脂肪组织和代谢之间的相互作用。(C)2011 Elsevier Inc. All rights reserved.
The majority of conditions associated with bone loss, including aging, are accompanied by increased marrow adiposity possibly due to shifting of the balance between osteoblast and adipocyte differentiation in bone marrow stromal (skeletal) stem cells (MSC). In order to study the relationship between osteoblastogenesis and adipogenesis in bone marrow, we have characterized cellular models of multipotent MSC as well as pre-osteoblastic and pre-adipocytic cell populations. Using these models, we identified two secreted factors in the bone marrow microenviroment: secreted frizzled-related protein 1 (sFRP-1) and delta-likel (preadipocyte factor 1) (Dlk1/Pref-1). Both exert regulatory effects on osteoblastogenesis and adipogenesis. Our studies suggest a model for lineage fate determination of MSC that is regulated through secreted factors in the bone marrow microenvironment that mediate a cross-talk between lineage committed cell populations in addition to controlling differentiation choices of multipotent MSC. This article is part of a Special Issue entitled: Interactions Between Bone, Adipose Tissue and Metabolism. (C) 2011 Elsevier Inc. All rights reserved.