Japanese encephalitis: surveillance and elimination effort in Japan from 1982 to 2004.
Japanese encephalitis: surveillance and elimination effort in Japan from 1982 to 2004.
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日本脑炎：1982 年至 2004 年日本的监测和消除工作。
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
I. Kurane
中科院分区：
文献类型：
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作者：
S. Arai;Y. Matsunaga;T. Takasaki;K. Tanaka;K. Taniguchi;N. Okabe;I. Kurane
日本脑炎（JE）监测自1965年以来一直作为日本国家疫苗接种疾病流行病学监测的一部分进行。1960年代末，每年报告的日本脑炎病例超过1，000例。自那时以来，日本脑炎病例数量明显减少，1992年至2004年每年报告的病例不到10例。1982年至2004年期间共报告了361例乙脑病例。320例患者的预后可用; 58例（18%）死亡，160例（50%）康复伴神经精神后遗症，102例（32%）完全康复。这些病例中有78%为40岁或以上，高峰年龄组为60-69岁。乙脑主要发生在未接种疫苗的人群中。每年都有很高的哨点猪的血清转化率。这表明，在日本大部分地区，包括1982年至2004年没有报告乙脑病例的北方地区，夏季都存在感染乙脑病毒的蚊子。虽然自1992年以来，日本脑炎病例的报告数为个位数，但日本脑炎病毒感染的风险仍然存在。因此，日本应保持乙脑疫苗的高免疫率。
Japanese encephalitis (JE) surveillance has been conducted since 1965 as a part of the National Epidemiological Surveillance of Vaccine Preventable Diseases in Japan. Over 1,000 JE cases were reported annually in the late 1960s. The number of JE cases has since markedly decreased, with less than 10 cases reported annually from 1992 to 2004. A total of 361 JE cases were reported between 1982 and 2004. Prognosis was available for 320 cases; 58 (18%) died, 160 (50%) recovered with neuropsychiatric sequelae, and 102 (32%) completely recovered. Seventy-eight percent of these cases were 40 years old or over with a peak age group of 60-69 years old. JE predominantly occurred in unvaccinated populations. A high seroconversion rate among sentinel pigs was recorded every year. This suggests the presence of JE virus-infected mosquitoes during the summer in most areas of Japan, including the northern districts where no JE cases were reported from 1982 to 2004. Although JE cases have been reported in single figures since 1992, the risk of JE virus infection is still present. Thus, high immunization rates of JE vaccine should be maintained in Japan.