Exercise and endorphins--male responses.
Exercise and endorphins--male responses.
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运动和内啡肽——男性的反应。
DOI：
10.1249/00005768-198502000-00014
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发表时间：
1985
影响因子：
4.1
通讯作者：
P. Farrell
中科院分区：
文献类型：
--
作者：
P. Farrell
20世纪70年代中期，内源性阿片类药物的发现引发了巨大的科学努力，试图确定这些肽的生理作用。迄今为止，所有研究人员都注意到运动后人类外周血中β -内啡肽水平的增加。这表明内源性阿片系统在运动过程中被激活，应该刺激研究者使用运动和训练作为模型来帮助理解这些肽。与大多数其他内分泌不同，血浆中-内啡肽的水平并不会随着工作强度的增加而增加。这一结论仅基于一项研究，需要进一步证实。迄今为止，所有的人类研究都使用了放射免疫测定法，但有一个例外，有趣的是，该研究显示亮氨酸脑啡肽样放射受体可测定配体的血浆水平没有一致的变化。在男性中，基本上没有关于训练对运动的急性或慢性反应的影响的信息。在人类和动物模型中使用阿片拮抗剂（受体类型特异性）的研究应该证明有助于证实或否定这些肽在食欲、疼痛感知、温度调节、代谢、通风和运动时血压控制中的作用。
The discovery of the endogenous opiates in the mid-1970's has led to a tremendous scientific effort attempting to determine the physiological role of these peptides. An increase in the peripheral plasma levels of beta-endorphin in humans after exercise has been noted by all investigators to date. This indication that the endogenous opiate system is activated during exercise should stimulate investigators to use exercise and training as models to aid in the understanding of these peptides. Unlike most other endocrines, plasma levels of beta-endorphin do not increase proportionally to work intensity. This conclusion is based on only one study and requires corroboration. All human studies to date have used radioimmunoassays, with one exception, and interestingly that study showed no consistent change in plasma levels of leucine enkephalin-like radioreceptor assayable ligands. In males, essentially no information is available concerning the effects of training on either acute or chronic responses to exercise. Studies using opiate antagonists (receptor type-specific) in human and animal models should prove useful in establishing or disproving roles for these peptides in appetite, pain perception, temperature regulation, metabolism, ventilation, and blood pressure control during exercise.