Bone turnover markers are correlated with quantitative ultrasound of the calcaneus: 5-year longitudinal data
Bone turnover markers are correlated with quantitative ultrasound of the calcaneus: 5-year longitudinal data
复制标题
骨转换标志物与跟骨定量超声相关：5 年纵向数据
DOI：
10.1007/s00198-008-0769-x
复制
发表时间：
2009
影响因子：
4
通讯作者：
K. Ivaska
中科院分区：
文献类型：
--
作者：
J. Lenora;P. Gerdhem;P. Gerdhem;P. Gerdhem;Karl Obrant;K. Ivaska;K. Ivaska
摘要 在 810 名老年女性的人群样本中研究了骨转换标志物与跟骨超声（定量超声，QUS）之间的关联。基线骨转换标志物与基线 QUS 以及 QUS 的 5 年前瞻性变化相关。简介骨转换标志物与面积骨矿物质密度相关，但与 QUS 关联的知识有限。方法对 810 名女性（均为 75 岁）进行了基线调查。 506 人完成了为期 5 年的随访。在基线时对骨转换标志物和跟骨 QUS [声速 (SoS)、宽带超声衰减 (BUA)、硬度]进行研究。结果所有骨转换标志物均与基线 QUS 相关[标准化回归 (Betastd) 值从 -0.07,p< 0.05 至 -0.23,p< 0.001]，但骨特异性碱性磷酸酶 (S-Bone ALP) 除外，它与 BUA 和硬度指数不相关。当分析基线骨转换标志物与QUS 5年变化之间的相关性时，三种血清骨钙素与SoS和硬度指数的变化相关（Betastd= −0.11，p< 0.05至-0.17，p< 0.001）。 S-CTX-I 还与 SoS 和硬度指数的变化相关（Betastd 分别= −0.10 和−0.09，p< 0.05）。 S-TRACP5b、尿脱氧吡啶啉/crea和U-MidOC/crea与SoS的变化相关（Betastd= −0.10且p< 0.05）。 S-Bone ALP 与 QUS 的变化不相关。没有一个骨转换标志物与 BUA 的变化相关。结论骨转换标志物与同时评估的 QUS 以及 QUS 的纵向变化相关。
SummaryAssociations between bone turnover markers and calcaneal ultrasound (quantitative ultrasound, QUS) were studied in a population-based sample of 810 elderly women. Baseline bone turnover markers correlated with baseline QUS as well as with 5-year prospective changes in QUS.IntroductionBone turnover markers are associated with areal bone mineral density, but the knowledge on the association with QUS is limited.MethodsEight hundred ten women, all 75 years old, were investigated at baseline. Five hundred six completed a 5-year follow-up. Bone turnover markers and calcaneal QUS [speed of sound (SoS), broadband ultrasound attenuation (BUA), stiffness] were investigated at baseline. QUS was investigated at follow-up.ResultsAll bone turnover markers were correlated with baseline QUS [standardized regression (Betastd) values from −0.07,p< 0.05 to −0.23,p< 0.001], with the exception of bone-specific alkaline phosphatase (S-Bone ALP) which was not correlated with BUA and stiffness index. When the correlations between baseline bone turnover markers and 5-year changes in QUS were analyzed, three serum osteocalcins were correlated with changes of SoS and stiffness index (Betastd= −0.11,p< 0.05 to −0.17,p< 0.001). Also S-CTX-I correlated with changes of SoS and stiffness index (Betastd= −0.10 and −0.09, respectively,p< 0.05). S-TRACP5b, urinary deoxypyridinoline/crea, and U-MidOC/crea correlated with changes of SoS (Betastd= −0.10 andp< 0.05 for all). S-Bone ALP did not correlate with change of QUS. None of the bone turnover markers correlated with changes of BUA.ConclusionsBone turnover markers correlate with concomitantly assessed QUS as well as with longitudinal change in QUS.
影响因子：
4
作者：
Delmas, PD;Eastell, R;Stepan, J
通讯作者：
Stepan, J
对于 JPOS 研究组：骨转换的生化标志物可预测围绝经期女性的骨质流失，但不能预测绝经后女性的骨质流失——日本人口骨质疏松症 (JPOS) 队列研究。
DOI：
--
发表时间：
2006
期刊：
Osteoporos Int. 17(7)
影响因子：
--
作者：
角田正史;辻雅善;木村幸子;張螢;菅谷ちえ美;井上葉子;工藤雄一朗;佐藤敏彦;片桐裕史;秋田久直;佐治眞理;土屋利江;相澤好治;Iki M
通讯作者：
Iki M
骨转换的生化标记物可预测骨质疏松症和骨质疏松性骨折。
DOI：
--
发表时间：
2005
期刊：
Osteoporos Jpn 13
影响因子：
--
作者：
Yoshimura N;Nakatsuka K
通讯作者：
Nakatsuka K