Testosterone modulates the differential release of luteinizing hormone and follicle-stimulating hormone that occurs in response to changing gonadotropin-releasing hormone pulse frequency in the male monkey, Macaca fascicularis.
Testosterone modulates the differential release of luteinizing hormone and follicle-stimulating hormone that occurs in response to changing gonadotropin-releasing hormone pulse frequency in the male monkey, Macaca fascicularis.
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睾酮调节黄体生成素和卵泡刺激素的差异释放，这是对雄性猴（食蟹猴）促性腺激素释放激素脉冲频率变化的反应。
DOI：
10.1095/biolreprod38.1.156
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发表时间：
1988
影响因子：
3.6
通讯作者：
Steiner,RA
中科院分区：
文献类型：
--
作者：
Adams,LA;Clifton,DK;Bremner,WJ;Steiner,RA
血浆促卵泡激素（FSH）水平的选择性升高是一些生理状况的特征，如人类青春期的早期阶段，以及一些睾丸功能障碍，如特发性少精症。我们测试了一个假设，即缓慢的促性腺激素释放激素（GnRH）脉冲频率有利于选择性地提高血浆促卵泡刺激素，这受循环类固醇环境的影响。我们以每90分钟一次（q 90分钟）和每240分钟一次（q 240分钟）的频率给阉割的青春期前雄猴注射外源性GnRH，这些雄猴在阉割时接受了空的（假的）或充满睾酮(T)的硅胶胶囊。在每个实验频率周期结束时，测量血浆中促黄体生成素（LH）和促卵泡刺激素（FSH）的平均水平。同时也测量了血浆T水平。植入T的动物血浆中这种激素水平在成人范围内（8 ng/ml），而假植入T的动物血浆中T水平在青春期前范围内（<0.4 ng/ml）。在假植入动物中，平均血浆FSH水平在较慢的GnRH脉冲频率下显著升高（GnRH q 240 min后为39.5±3.6 ng/ml，而GnRH q 90 min后为23.7±2.8 ng/ml）。这种选择性FSH升高在T植入的动物中不明显。在两种GnRH脉冲频率下，t治疗和假植入动物的平均血浆LH水平相似（= 8 μg/m1）。因此，缓慢的GnRH脉冲频率有利于血浆FSH的选择性升高，但仅当血浆T水平较低时，因为当T水平在正常成人范围内时，这种升高被阻断。
Selective elevations of plasma follicle-stimulating hormone (FSH) levels are characteristic of some physiological conditions, such as the early stages of human puberty, and in some disorders of testicular function, such as idiopathic oligospermia. Ve tested the hypotheses that a slow gonadotropin-releasing hormone (GnRH) pulse frequency favors a selective elevation of plasma FSH and that this is influenced by the circulating steroidal milieu. We administered exogenous GnRH at frequencies of once every 90 min (q 90 min) and once every 240 min (q 240 min) to castrated prepubertal male monkeys who had received either empty (sham) or testosterone (T)-filled Silastic capsules at the time of castration. At the end of each experimental frequency period, mean plasma levels of luteinizing hormone (LH) and FSH were measured. Plasma T levels were also measured. Animals with T implants had plasma levels of this hormone that were in the adult range (≅8 ng/ml), whereas those with sham implants had plasma T levels in the prepubertal range (<0.4 ng/ml). In animals with sham implants, mean plasma FSH levels were markedly elevated at the slower GnRH pulse frequency (39.5 ± 3.6 ng/ml following GnRH q 240 min compared with 23.7 ± 2.8 ng/ml following GnRH q 90 min). This selective FSH elevation was not apparent in animals with T implants. Mean plasma LH levels were similar (≅8 μg/m1) at the two GnRH pulse frequencies, in both T-treated and sham-implanted animals. Thus, a slow GnRH pulse frequency favored a selective elevation of plasma FSH, but only when plasma T levels were low, since this elevation was blocked when T levels were in the normal adult range.