ACTH and beta-endorphin-related peptides are present in multiple sites in the reproductive tract of the male rat.
ACTH and beta-endorphin-related peptides are present in multiple sites in the reproductive tract of the male rat.
复制标题
ACTH 和 β-内啡肽相关肽存在于雄性大鼠生殖道的多个部位。
作者：
S. Tsong;D. Phillips;N. Halmi;A. Liotta;A. Margioris;C. Bardin;D. Krieger
免疫组织化学β-内啡肽和ACTH存在于睾丸间质细胞的细胞质和附睾、精囊的上皮细胞中，和大鼠的输精管。β-内啡肽的免疫染色强度不因垂体切除术而改变，并且去势后附睾染色持续存在。β-内啡肽、γ-内啡肽以及N-和C-末端ACTH活性也通过雄性组织提取物的X射线免疫测定法检测到，并且它们的浓度在垂体切除术后不降低。因此，这些肽似乎是局部的，而不是垂体的起源，并可能在生殖道内的旁分泌功能。
Immunostainable β-endorphin and ACTH are present in the cytoplasm of Leydig cells and in the epithelium of the epididymis, seminal vesicle., and yas deferens of rats,. The intensity of immunostaining for β- endorphin is not altered by hypophysectomy, and epididymal staining persists after (Castration, β-endorphin, γ-endorphin, and N- and C-terminal ACTH activities are also detected by xadioimmunoassay of male tissue extracts, and their concentrations do not decrease following hypophysectomy. These peptides therefore appear to be of local rather than pituitary origin and may serve a paracrine function within the reproductive tract.