Frameless stereotactic neuronavigated biopsy: A retrospective study of morbidity, diagnostic yield, and the potential of fluorescence A single-center clinical investigation
Frameless stereotactic neuronavigated biopsy: A retrospective study of morbidity, diagnostic yield, and the potential of fluorescence A single-center clinical investigation
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DOI：
10.1016/j.clineuro.2019.03.004
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发表时间：
2019-06-01
影响因子：
1.9
通讯作者：
Poulsen, Frantz R.
中科院分区：
文献类型：
--
作者：
Aebelo, Andreas M.;Noera, Victor R.;Poulsen, Frantz R.
目的：这项回顾性研究的主要目的是评估使用或不使用荧光素的无框架立体定向神经导航颅内活检的诊断率和发病率/死亡率。 患者和方法：使用 ICD-10 程序代码 AAGOO 识别 2007 年 1 月至 2017 年 12 月的患者病例。从电子病历中回顾性收集包括组织学诊断在内的相关临床数据，并由两位作者独立审查。结果：对来自 103 名患者的 111 份活检进行了鉴定。其中，109 例活检获得诊断，诊断率为 98.2%。 13 例活检中使用了荧光素（11.7%）。 12 名患者（10.8%）出现术后并发症，手术死亡率为 1.8%。在 12.6% 的病例中，活检显示炎症或非特异性反应性变化。根据是否使用术中组织学检查，在诊断率或并发症的数量和严重程度方面没有观察到统计学上的显着差异。结论：尽管由于对诊断率的定义缺乏共识，因此很难在研究之间进行直接比较，但本研究报告了与其他研究相似的诊断率。术中组织病理学分析似乎没有带来额外的好处。
Objective: The primary objective of this retrospective study was to evaluate the diagnostic yield and morbidity/mortality associated with frameless stereotactic neuronavigated intracranial biopsies with and without the use of fluorescein.Patients and methods: Patient cases from January 2007 to December 2017 were identified using the ICD-10 procedure code AAGOO. Relevant clinical data, including histological diagnosis, were collected retrospectively from the electronic patient charts and independently reviewed by two authors.Results: 111 biopsies obtained from 103 patients were identified. Of these, 109 biopsies yielded a diagnosis and resulted in a diagnostic yield of 98.2%. Fluorescein was used in 13 biopsies (11.7%). Twelve patients (10.8%) experienced postoperative complications, and the mortality attributed to the surgery was 1.8%. In 12.6% of cases, the biopsies showed inflammation or nonspecific reactive changes. No statistically significant differences were observed in diagnostic yield or number and severity of complications according to whether intraoperative histological examination was used or not.Conclusion: Although direct comparisons between studies are difficult due to lack of consensus about the definition of diagnostic yield, the present study reports a similar diagnostic yield to other studies. Intraoperative histopathological analysis appeared to give little extra benefit.