Transmission of a newly characterized strain of varicella-zoster virus from a patient with herpes zoster in a long-term-care facility, West Virginia, 2004
Transmission of a newly characterized strain of varicella-zoster virus from a patient with herpes zoster in a long-term-care facility, West Virginia, 2004
复制标题
DOI：
10.1086/527419
复制
发表时间：
2008-03-01
影响因子：
6.4
通讯作者：
Schmid, D. Scott
中科院分区：
文献类型：
--
作者：
Lopez, Adriana S.;Burnett-Hartman, Andrea;Schmid, D. Scott
我们调查了一个长期护理机构带状疱疹病例后的水痘小爆发。临床标本和环境样本收集所有病例患者和表面的病例患者的房间和其他常用区域。在所有3例水痘病例患者中均检测到野生型水痘-带状疱疹病毒（VZV）DNA，并在带状疱疹病例患者房间的环境样本中检测到高浓度的VZV DNA。基因型分析表明，相同的VZV毒株存在于所有样品中;此外，该菌株是一种独特的马赛克基因型分离株，其中包括迄今为止从未在VZV野生型菌株中观察到的稳定的Oka疫苗标记。这项研究提供了证据的价值，包括在调查水痘暴发的环境采样，并说明了评估多种疫苗相关的标志物的区别疫苗病毒从野生型VZV。
We investigated a small outbreak of varicella in a long-term-care facility after a case of herpes zoster. Clinical specimens and environmental samples were collected from all case patients and from surfaces in the case patients' rooms and other common-use areas. Wild-type varicella-zoster virus (VZV) DNA was identified in all 3 varicella case patients, and high concentrations of VZV DNA were detected in environmental samples from the room of the herpes zoster case patient. Genotypic analysis showed that the identical VZV strain was present in all samples; moreover, the strain was a unique Mosaic genotype isolate that included a stable Oka vaccine marker that had hitherto never been observed in a wild-type strain of VZV. This study provides evidence for the value of including environmental sampling during the investigation of varicella outbreaks and illustrates the importance of evaluating multiple vaccine-associated markers for the discrimination of vaccine virus from wild-type VZV.