Circadian clocks and metabolism.
Circadian clocks and metabolism.
复制标题
DOI：
10.1007/978-3-642-25950-0_6
复制
发表时间：
2013
影响因子：
--
通讯作者：
Bass, Joseph
中科院分区：
文献类型：
--
作者：
Marcheva, Biliana;Ramsey, Kathryn M;Peek, Clara B;Affinati, Alison;Maury, Eleonore;Bass, Joseph
生物钟在行为、生理和新陈代谢的内部循环中保持周期性，使生物体能够预测地球24小时的自转。在哺乳动物中，代谢系统的昼夜节律整合优化了光/暗循环中的能量收集和利用。最近，生物钟基因的破坏与睡眠障碍和心脏代谢疾病的发展有关。相反，异常的营养信号会影响行为的昼夜节律。本章回顾了分子钟和代谢系统之间的新关系，并检查了昼夜节律中断对人类健康产生有害影响的证据。
Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals, circadian integration of metabolic systems optimizes energy harvesting and utilization across the light/dark cycle. Disruption of clock genes has recently been linked to sleep disorders and to the development of cardiometabolic disease. Conversely, aberrant nutrient signaling affects circadian rhythms of behavior. This chapter reviews the emerging relationship between the molecular clock and metabolic systems and examines evidence that circadian disruption exerts deleterious consequences on human health.