New-onset diabetes after kidney transplantation:: Risk factors
New-onset diabetes after kidney transplantation:: Risk factors
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DOI：
10.1681/asn.2006080929
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发表时间：
2006-12-01
影响因子：
13.6
通讯作者：
Arias, Manuel
中科院分区：
文献类型：
--
作者：
Rodrigo, Emilio;Fernandez-Fresnedo, Gema;Arias, Manuel
移植后新发糖尿病 (NODAT) 会增加心血管疾病和感染的风险，从而降低移植物和患者的生存率。为了改善肾移植受者的预后，准确了解导致 NODAT 发展的危险因素非常有意义。发生 NODAT 的不可改变的危险因素包括年龄、种族、遗传背景、糖尿病家族史和既往葡萄糖不耐症。可改变的危险因素包括肥胖和超重、丙型肝炎病毒和巨细胞病毒感染以及免疫抑制药物。类固醇和钙调神经磷酸酶抑制剂都会影响 NODAT 的出现，而西罗莫司在葡萄糖代谢中的作用目前尚存在争议。
New-onset diabetes after transplantation (NODAT) contributes to the risk for cardiovascular disease and infection, reducing graft and patient survival. For improvement of the outcome of kidney transplant recipients, it is of great interest to know precisely the risk factors that contribute to NODAT development. Nonmodifiable risk factors for development of NODAT are age, race, genetic background, family history of diabetes, and previous glucose intolerance. Modifiable risk factors are obesity and overweight, hepatitis C virus and cytomegalovirus infections, and immunosuppressive drugs. Both steroids and calcineurin inhibitors influence the appearance of NODAT, whereas the role of sirolimus in glucose metabolism currently is controversial.