Two new aromatic polyketides from a sponge-derived Fusarium
Two new aromatic polyketides from a sponge-derived Fusarium
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DOI：
10.3762/bjoc.15.289
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发表时间：
2019-12
影响因子：
2.7
通讯作者：
M. Sibero;Tao Zhou;K. Fukaya;D. Urabe;O. Radjasa;A. Sabdono;A. Trianto;Y. Igarashi
中科院分区：
文献类型：
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作者：
M. Sibero;Tao Zhou;K. Fukaya;D. Urabe;O. Radjasa;A. Sabdono;A. Trianto;Y. Igarashi
在我们的海洋真菌天然产物筛选项目中，从印度尼西亚海绵Xestospongia sp.的海绵共生镰刀菌属真菌（Fusarium sp. KJMT.FP.4.3）中分离到两个新的芳香聚酮karimunones A（1）和B（2），以及五个已知化合物（3-7）。1的NMR归属由基于DFT的理论化学位移计算辅助。化合物2显示出对多重耐药性肠道沙门氏菌伤寒血清型的抗菌活性，MIC为125 μg/mL，而1没有活性。
In our natural product screening program from marine fungi, two new aromatic polyketides karimunones A (1) and B (2) and five known compounds (3–7) were isolated from sponge-associated Fusarium sp. KJMT.FP.4.3 which was collected from an Indonesian sponge Xestospongia sp. The structures of these compounds were determined by the analysis of NMR and MS spectroscopic data. The NMR assignment of 1 was assisted by DFT-based theoretical chemical shift calculation. Compound 2 showed antibacterial activity against multidrug resistant Salmonella enterica ser. Typhi with a MIC of 125 µg/mL while 1 was not active.