Studies on pectin coating of liposomes for drug delivery
Studies on pectin coating of liposomes for drug delivery
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DOI：
10.1016/j.colsurfb.2011.07.058
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发表时间：
2011-12-01
影响因子：
5.8
通讯作者：
Smistad, Gro
中科院分区：
文献类型：
--
作者：
Sanko Nguyen;Alund, Siv Jorunn;Smistad, Gro
本研究通过粒径测定和zeta电位测量研究了三种不同类型的果胶（LM、HM和酰胺化果胶）对荷电脂质体的表面包覆。通过原子力显微镜观察果胶和果胶包被的脂质体。果胶吸附到阳性脂质体上产生了可重现的颗粒大小的增加和zeta电位从正向负侧的所有三种果胶类型的移位，而果胶吸附到阴性脂质体上没有呈现任何显着的变化，可能是由于静电排斥。用HM-果胶包被的阳性脂质体得到最大的果胶包被颗粒，具有最小的负ζ电位，而对于LM-果胶包被的阳性脂质体观察到相反的情况。此外，动态光散射的结果显示窄的尺寸分布，表明果胶包覆的脂质体的聚集程度低。由于脂质体能够包封药物，并且已经发现果胶具有粘膜粘附性，因此这些果胶包衣的脂质体可能是潜在的药物递送系统。(C)2011 Elsevier B. V.保留所有权利。
The present study investigated the surface coating of charged liposomes by three different types of pectin (LM, HM and amidated pectin) by particle size determinations and zeta potential measurements. The pectins and the pectin coated liposomes were visualized by atomic force microscopy. The adsorption of pectin onto positive liposomes yielded a reproducible increase in particle size and a shift of the zeta potential from positive to negative side for all three pectin types, whereas the adsorption of pectin onto negative liposomes did not render any significant changes probably due to electrostatic repulsion. The positive liposomes coated with HM-pectin gave the largest pectin coated particles with the least negative zeta potential, while the opposite was observed for the LM-pectin coated positive liposomes. Furthermore, results from dynamic light scattering revealed narrow size distributions, indicating that the degree of aggregation was low for the pectin coated liposomes. As liposomes are able to encapsulate drugs and pectin has been found to be mucoadhesive, these pectin coated liposomes may be potential drug delivery systems. (C) 2011 Elsevier B.V. All rights reserved.