Importins and exportins in cellular differentiation.
Importins and exportins in cellular differentiation.
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DOI：
10.1111/j.1582-4934.2008.00437.x
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发表时间：
2008-10
影响因子：
5.3
通讯作者：
Isemura M
中科院分区：
文献类型：
--
作者：
Okada N;Ishigami Y;Suzuki T;Kaneko A;Yasui K;Fukutomi R;Isemura M
输入/输出转运系统提供参与核质转运的机制。进出口水平的变化可能在发展、分化和转型中发挥关键作用。利用人白血病HL-60细胞，我们和其他人揭示了这些因子的蛋白质和基因表达的分化相关变化。最近的发现，输入蛋白-α亚型的转换触发胚胎干细胞的神经分化强调了核质转运因子在细胞事件中的重要性。本文就importins和exportins在细胞分化中的作用作一综述。
The importin/exportin transport system provides the machinery involved in nucleocytoplasmic transport. Alterations of the levels of importins and exportins may play crucial roles in development, differentiation and transformation. Employing human leukaemia HL-60 cells, we and others have revealed the differentiation-associated changes in the protein and gene expression of these factors. The recent finding that a switch to the importin-α subtype triggers neural differentiation of embryonic stem cells underscores the importance of nucleocytoplasmic transport factors in cellular events. This review focuses on current research into the roles of importins and exportins in cell differentiation.