Is the cellular response to cigarette smoke predictive of the phenotypic variation of COPD?
Is the cellular response to cigarette smoke predictive of the phenotypic variation of COPD?
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DOI：
10.1152/ajplung.00108.2011
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发表时间：
2011-06-01
影响因子：
4.9
通讯作者：
Christman, John W.
中科院分区：
文献类型：
--
作者：
Park, Gye Young;Christman, John W.
吸烟对健康的不良影响不仅限于肺部，还包括直接或间接暴露于烟草燃烧产生的有害气体和可溶性化合物的其他多个器官系统的影响。吸烟（CS）是许多重大疾病的危险因素，包括慢性阻塞性肺疾病（COPD）、动脉粥样硬化、脑和冠状动脉疾病、高血压和许多类型的癌症。在慢性阻塞性肺病的诊断范畴内，人们普遍认为在肺和肺外表现方面存在实质性的表型异质性。为了理解对CS反应的可变性，有必要在细胞和分子水平上破译导致卷烟相关病理的相关机制。在这一期的Journal中，有三篇论文（1,4,6）通过检查三种类型的肺细胞：内皮细胞、上皮细胞和免疫效应细胞，为cs相关性COPD的分子发病机制提供了可能与表型变异相关的见解。
THE ADVERSE HEALTH CONSEQUENCES of cigarette smoking are not limited to the lung but also include effects on multiple other organ systems that are exposed directly or indirectly to the hazardous gaseous and soluble compounds generated by burning tobacco. Cigarette smoking (CS) is a risk factor for many major diseases including chronic obstructive pulmonary disease (COPD), atherosclerosis, cerebral and coronary vascular diseases, hypertension, and many types of cancer. Within the diagnosis category of COPD, it is widely recognized that there is substantial phenotypic heterogeneity with respect to both pulmonary and extrapulmonary manifestations. To understand the variability in responses to CS, it becomes essential to decipher the involved mechanisms at a cellular and molecular level that contribute to cigarette-related pathology. In this issue of the Journal, there are three papers (1, 4, 6) that provide insight regarding the molecular pathogenesis of CS-related COPD that could be related to phenotypic variation, by examining three classes of cell types of lung: endothelial cells, epithelial cells, and immune effector cells.