Imaging Foveal Microvasculature: Optical Coherence Tomography Angiography Versus Adaptive Optics Scanning Light Ophthalmoscope Fluorescein Angiography.
Imaging Foveal Microvasculature: Optical Coherence Tomography Angiography Versus Adaptive Optics Scanning Light Ophthalmoscope Fluorescein Angiography.
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DOI：
10.1167/iovs.15-18932
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发表时间：
2016-07-01
影响因子：
4.4
通讯作者：
Rosen RB
中科院分区：
文献类型：
--
作者：
Mo S;Krawitz B;Efstathiadis E;Geyman L;Weitz R;Chui TY;Carroll J;Dubra A;Rosen RB
比较光学相干断层扫描血管造影 (OCTA) 和自适应光学扫描光检眼镜荧光素血管造影 (AOSLO FA) 在表征健康和血管病变眼睛的中心凹微脉管系统方面的应用。使用 OCTA 和 AOSLO FA 对 4 名健康对照者和 11 名血管病变患者（4 名糖尿病视网膜病变、4 名视网膜静脉阻塞和 3 名镰状细胞性视网膜病变）进行了成像。中心凹灌注图被半自动骨架化以进行定量分析，其中包括中心凹无血管区（FAZ）指标（面积、周长、无循环指数）和三个同心环形感兴趣区域的血管密度。在每组 OCTA 和 AOSLO FA 图像上，使用匹配的血管段进行管腔直径测量。通过微动脉瘤、血管环、渗漏和血管段的视觉识别来进行定性图像比较。自适应光学扫描光检眼镜 FA 和 OCTA 显示 FAZ 周长、圆度指数和血管密度没有统计学上的显着差异。然而，中心凹无血管区面积显示出很小但具有统计学意义的差异，为 1.8% (P = 0.004)。 OCTA 上的管腔直径明显更大（平均差异 5.7 μm，P < 0.001）。微动脉瘤、血管袢的精细结构、渗漏和一些血管片段在 AOSLO FA 上可见，但在 OCTA 上看不到，而被渗漏遮盖的血管仅在 OCTA 上可见。除了 FAZ 面积、管腔直径和一些定性特征方面的差异外，光学相干断层扫描血管造影在中心凹微血管成像方面与 AOSLO FA 相当。这些结果加上其易用性、采集时间短和避免潜在的光毒性蓝光，支持 OCTA 作为监测眼部病理学和检测早期疾病的工具。
To compare the use of optical coherence tomography angiography (OCTA) and adaptive optics scanning light ophthalmoscope fluorescein angiography (AOSLO FA) for characterizing the foveal microvasculature in healthy and vasculopathic eyes. Four healthy controls and 11 vasculopathic patients (4 diabetic retinopathy, 4 retinal vein occlusion, and 3 sickle cell retinopathy) were imaged with OCTA and AOSLO FA. Foveal perfusion maps were semiautomatically skeletonized for quantitative analysis, which included foveal avascular zone (FAZ) metrics (area, perimeter, acircularity index) and vessel density in three concentric annular regions of interest. On each set of OCTA and AOSLO FA images, matching vessel segments were used for lumen diameter measurement. Qualitative image comparisons were performed by visual identification of microaneurysms, vessel loops, leakage, and vessel segments. Adaptive optics scanning light ophthalmoscope FA and OCTA showed no statistically significant differences in FAZ perimeter, acircularity index, and vessel densities. Foveal avascular zone area, however, showed a small but statistically significant difference of 1.8% (P = 0.004). Lumen diameter was significantly larger on OCTA (mean difference 5.7 μm, P < 0.001). Microaneurysms, fine structure of vessel loops, leakage, and some vessel segments were visible on AOSLO FA but not OCTA, while blood vessels obscured by leakage were visible only on OCTA. Optical coherence tomography angiography is comparable to AOSLO FA at imaging the foveal microvasculature except for differences in FAZ area, lumen diameter, and some qualitative features. These results, together with its ease of use, short acquisition time, and avoidance of potentially phototoxic blue light, support OCTA as a tool for monitoring ocular pathology and detecting early disease.