Vitamin D Receptor Genetic Polymorphism Is Significantly Associated with Risk of Type 2 Diabetes Mellitus in Chinese Han Population
Vitamin D Receptor Genetic Polymorphism Is Significantly Associated with Risk of Type 2 Diabetes Mellitus in Chinese Han Population
复制标题
维生素D受体基因多态性与中国汉族人群2型糖尿病风险显着相关
DOI：
10.1016/j.arcmed.2015.09.006
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发表时间：
2015-10-01
影响因子：
7.7
通讯作者：
Shen, Chong
中科院分区：
文献类型：
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作者：
Jia, Jian;Ding, Haixia;Shen, Chong
背景和目标。我们研究了维生素D受体（VDR）基因多态性对中国汉族人群2型糖尿病（T2 DM）风险的影响。采用TaqMan方法对669例T2 DM患者、1084例空腹血糖受损（IFG）患者和1961例空腹血糖正常对照者进行tagSNPs（rs 11574129、rs 2228570和rs739837）基因分型。通过调整年龄、性别、体重指数（BMI）和吸烟等协变量，应用多元逻辑回归分析SNPs与糖尿病风险的关联。采用一般线性模型（GLM）比较不同基因型的空腹血糖水平，并校正混杂因素。结果显示rs739837在加性模型（OR = 1.166，95%CI 1.017-1.337，p = 0.028）和显性模型（OR = 1.166，95%CI 1.017-1.337，p = 0.002）中与T2 DM风险增加显著相关。分层分析显示rs739837和rs 2228570分别与女性和男性T2 DM相关。在人群中发现三个SNPs与T2 DM之间存在显著关联
Background and Aims. We investigated the effect of vitamin D receptor (VDR) gene polymorphism on the risk of type 2 diabetes mellitus (T2DM) in a Chinese Han population.Methods. Three tagSNPs (rs11574129, rs2228570 and rs739837) were genotyped using TaqMan assays in a case-control study including 669 cases with T2DM, 1084 individuals with impaired fasting glucose (IFG) and 1961controls with normal fasting glucose. Multiple logistic regression was applied to analyze the association of SNPs and the risk of diabetes by adjusting for covariates including age, sex, body mass index (BMI) and smoking. General linear model (GLM) was applied to compare fasting blood glucose levels between genotypes and adjusted for confounding factors.Results. The results showed that rs739837 was significantly associated with increased risk of T2DM in additive model (OR = 1.166, 95% CI 1.017-1.337, p = 0.028) and dominant (OR = 1.166, 95% CI 1.017-1.337, p = 0.002) model. Stratified analysis showed that rs739837 and rs2228570 were, respectively, correlated with T2DM in females and males. Significant associations were found between three SNPs and T2DM in the population