Taxane-mediated antiangiogenesis in vitro:: Influence of formulation vehicles and binding proteins
Taxane-mediated antiangiogenesis in vitro:: Influence of formulation vehicles and binding proteins
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DOI：
10.1158/0008-5472.can-03-3391
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发表时间：
2004-02-01
期刊：
影响因子：
11.2
通讯作者：
Sparreboom, A
中科院分区：
文献类型：
--
作者：
Ng, SSW;Figg, WD;Sparreboom, A
紫杉醇（Taxol）和多西他赛（Taxotere）已被证明在不影响癌细胞增殖的低浓度下抑制血管生成。在这里，我们使用大鼠主动脉环和人脐静脉内皮细胞，以评估其配方车辆Cremophor EL和聚山梨酯80，以及血清结合蛋白对紫杉烷介导的抗血管生成的影响。数据显示，载体和结合蛋白的临床相关浓度使两种紫杉烷的抗血管生成活性无效。这表明，这些药物可能需要使用更高的剂量比预期有效的抗血管生成化疗。
Paclitaxel (Taxol) and docetaxel (Taxotere) have been shown to inhibit angiogenesis at low concentrations that do not affect cancer cell proliferation. Here, we used rat aortic rings and human umbilical vein endothelial cells to evaluate the influence of their formulation vehicles Cremophor EL and polysorbate 80, as well as serum binding proteins on taxane-mediated antiangiogenesis. The data show that clinically relevant concentrations of the vehicles and binding proteins nullify the antiangiogenic activity of both taxanes. It is suggested that these agents may need to be used at much higher doses than anticipated for effective antiangiogenic chemotherapy.