Expanding TOR Complex 2 Signaling: Emerging Regulators and New Connections.
Expanding TOR Complex 2 Signaling: Emerging Regulators and New Connections.
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DOI：
10.3389/fcell.2021.713806
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发表时间：
2021
影响因子：
5.5
通讯作者：
Luo Y
中科院分区：
文献类型：
--
作者：
An P;Xu W;Luo J;Luo Y
在其开创性发现近三十年后，我们对TOR通路的理解继续扩大。作为一种TOR复合物，TORC 2位于许多信号通路的连接处，并通过整合环境和细胞内信号来指导多种基本过程，如细胞存活、增殖和代谢。TORC2活性的失调破坏细胞内稳态并导致许多病理生理学状况。随着对信号转导图谱的持续努力，近年来TORC 2调控的发现速度加快。因此，新出现的证据已经扩大了上游调节器的库，并揭示了TORC 2调节模式的意外多样性。多个环境线索和质膜蛋白微调TORC 2活动正在展开。此外，TORC2信号传导与其他主要信号传导途径错综复杂地交织在一起。因此，反馈和串扰调节也广泛地调制TORC 2。在这种情况下，我们提供了一个全面的概述革命性的概念，新兴的监管机构TORC2和讨论的证据反馈和串扰调节，揭示了新的光TORC2生物学。
Almost three decades after its seminal discovery, our understanding of the remarkable TOR pathway continues to expand. As a TOR complex, TORC2 lies at the nexus of many signaling pathways and directs a diverse array of fundamental processes such as cell survival, proliferation, and metabolism by integrating environmental and intracellular cues. The dysregulation of TORC2 activity disrupts cellular homeostasis and leads to many pathophysiological conditions. With continued efforts at mapping the signaling landscape, the pace of discovery in TORC2 regulation has been accelerated in recent years. Consequently, emerging evidence has expanded the repertoire of upstream regulators and has revealed unexpected diversity in the modes of TORC2 regulation. Multiple environmental cues and plasma membrane proteins that fine-tune TORC2 activity are unfolding. Furthermore, TORC2 signaling is intricately intertwined with other major signaling pathways. Therefore, feedback and crosstalk regulation also extensively modulate TORC2. In this context, we provide a comprehensive overview of revolutionary concepts regarding emerging regulators of TORC2 and discuss evidence of feedback and crosstalk regulation that shed new light on TORC2 biology.
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影响因子：
82.9
作者：
Chen, Chien-Ju;Sgritta, Martina;Costa-Mattioli, Mauro
通讯作者：
Costa-Mattioli, Mauro
影响因子：
7.3
作者：
Baffi TR;Lordén G;Wozniak JM;Feichtner A;Yeung W;Kornev AP;King CC;Del Rio JC;Limaye AJ;Bogomolovas J;Gould CM;Chen J;Kennedy EJ;Kannan N;Gonzalez DJ;Stefan E;Taylor SS;Newton AC
通讯作者：
Newton AC
DOI：
10.1073/pnas.1019386108
发表时间：
2011-08-30
影响因子：
11.1
作者：
Gao, Xinxin;Lowry, Pamela R.;Zhang, Jin
通讯作者：
Zhang, Jin
影响因子：
4.8
作者：
Artinian, Nicholas;Cloninger, Cheri;Gera, Joseph
通讯作者：
Gera, Joseph
影响因子：
5.3
作者：
Dibble, Christian C.;Asara, John M.;Manning, Brendan D.
通讯作者：
Manning, Brendan D.