Margination of red blood cells infected by Plasmodium falciparum in a microvessel
Margination of red blood cells infected by Plasmodium falciparum in a microvessel
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DOI：
10.1016/j.jbiomech.2011.02.084
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发表时间：
2011-05-17
影响因子：
2.4
通讯作者：
Yamaguchi, Takami
中科院分区：
文献类型：
--
作者：
Imai, Yohsuke;Nakaaki, Keita;Yamaguchi, Takami
本文研究了恶性疟原虫感染的红细胞（pf - irbc）在微尺度血流中的边缘化机制。我们的模型表明，处于滋养体阶段的Pf-IRBC （Pf-T-IRBC）与健康红细胞（hrbc）之间持续的流体动力学相互作用导致Pf-T-IRBC的边缘化，因此，与内皮细胞接触的持续时间更长。f- t - irbc和hrbc首先形成一个“列车”。然后，红细胞的体积分数局部增加，约为40%，并且由于在高红细胞比容条件下形成长列，该值可以维持很长一段时间。即使在低红细胞比容条件下，局部体积分数也会瞬间升高到40%，并且Pf-T-IRBC可以迁移到壁上。然而，在低红细胞比容条件下形成的短链不能提供持续的相互作用，并且Pf-T-IRBC移回通道的中心。(C) 2011 Elsevier Ltd.版权所有。
We investigated numerically the mechanism of margination of Plasmodium falciparum malaria-infected red blood cells (Pf-IRBCs) in micro-scale blood flow. Our model illustrates that continuous hydrodynamic interaction between a Pf-IRBC in the trophozoite stage (Pf-T-IRBC) and healthy red blood cells (HRBCs) results in the margination of the Pf-T-IRBC and, thus, a longer duration of contact with endothelial cells. The Pf-T-IRBC and HRBCs first form a "train". The volume fraction of RBCs is then locally increased, to approximately 40%, and this value is maintained for a long period of time due to the formation of a long train in high-hematocrit conditions. Even in low-hematocrit conditions, the local volume fraction is instantaneously elevated to 40% and the Pf-T-IRBC can migrate to the wall. However, the short train formed in low-hematocrit conditions does not provide continuous interaction, and the Pf-T-IRBC moves back to the center of the channel. (C) 2011 Elsevier Ltd. All rights reserved.