Molecular mechanics of RNA translocases.
Molecular mechanics of RNA translocases.
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DOI：
10.1016/b978-0-12-396546-2.00006-1
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发表时间：
2012
影响因子：
--
通讯作者：
Pyle, Anna Marie
中科院分区：
文献类型：
--
作者：
Ding, Steve C.;Pyle, Anna Marie
从历史上看，对RNA解旋酶和易位酶的研究似乎是dna重塑酶研究取得巨大进展的一个注脚。然而，在过去的十年中，RNA科学活动的兴起引起了人们对改造RNA分子的特殊运动酶行为的强烈兴趣。对这些RNA酶的功能、机制和结构的研究已经开始揭示它们在RNA代谢和信号传导中的关键作用的分子基础。在本章中，我们强调了单体RNA转位酶之间的结构和机制相似性，同时强调了许多不同的特性，这些特性使该酶家族成为代谢和基因表达中最重要的酶之一。
Historically, research on RNA helicase and translocation enzymes has seemed like a footnote to the extraordinary progress in studies on DNA-remodeling enzymes. However, during the past decade, the rising wave of activity in RNA science has engendered intense interest in the behaviors of specialized motor enzymes that remodel RNA molecules. Functional, mechanistic, and structural investigations of these RNA enzymes have begun to reveal the molecular basis for their key roles in RNA metabolism and signaling. In this chapter, we highlight the structural and mechanistic similarities among monomeric RNA translocase enzymes, while emphasizing the many divergent characteristics that have caused this enzyme family to become one of the most important in metabolism and gene expression.