The history of biodegradable magnesium implants: A review
The history of biodegradable magnesium implants: A review
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DOI：
10.1016/j.actbio.2010.02.028
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发表时间：
2010-05-01
影响因子：
9.7
通讯作者：
Witte, Frank
中科院分区：
文献类型：
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作者：
Witte, Frank
今天，在汉弗莱·戴维爵士于1808年首次生产金属镁200多年后，可生物降解的镁基金属植入物目前正在打破生物材料科学的范式，只开发高度耐腐蚀的金属。这种开创性的临时金属植入物是生物材料科学的最新发展之一，正在被重新发现。这是一个具有挑战性的话题，仍然存在一些秘密，可能会彻底改变目前临床使用的各种生物医学植入物。镁合金作为种植材料的研究由来已久。1878年，医生爱德华·c·豪斯（Edward C. house）给出了一份非常早期的临床报告。他用镁线捆扎流血的血管。在过去的两个世纪里，镁合金的临床应用主要是由具有各种临床背景的外科医生进行的，如心血管、肌肉骨骼和普通外科。几乎所有患者都从镁植入治疗中获益。虽然大多数患者出现种植体快速腐蚀引起的皮下气腔，但大多数患者在术后随访中没有疼痛，几乎没有感染。本文综述了镁合金在生物降解金属领域的研究进展，综述了镁合金在生物降解金属领域的研究进展。(C) 2010材料学报Elsevier Ltd.出版。版权所有。
Today, more than 200 years after the first production of metallic magnesium by Sir Humphry Davy in 1808, biodegradable magnesium-based metal implants are currently breaking the paradigm in biomaterial science to develop only highly corrosion resistant metals. This groundbreaking approach to temporary metallic implants is one of the latest developments in biomaterials science that is being rediscovered. It is a challenging topic, and several secrets still remain that might revolutionize various biomedical implants currently in clinical use. Magnesium alloys were investigated as implant materials long ago. A very early clinical report was given in 1878 by the physician Edward C. Huse. He used magnesium wires as ligature for bleeding vessels. Magnesium alloys for clinical use were explored during the last two centuries mainly by surgeons with various clinical backgrounds, such as cardiovascular, musculoskeletal and general surgery. Nearly all patients benefited from the treatment with magnesium implants. Although most patients experienced subcutaneous gas cavities caused by rapid implant corrosion, most patients had no pain and almost no infections were observed during the postoperative follow-up. This review critically summarizes the in vitro and in vivo knowledge and experience that has been reported on the use of magnesium and its alloys to advance the field of biodegradable metals. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.