Human muscle-derived cell injection in a rat model of stress urinary incontinence.
Human muscle-derived cell injection in a rat model of stress urinary incontinence.
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在压力性尿失禁大鼠模型中注射人肌肉源性细胞。
DOI：
10.1002/mus.20827
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发表时间：
2007
期刊：
影响因子：
3.4
通讯作者：
Chancellor,MichaelB
中科院分区：
文献类型：
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作者：
Kim,YongTae;Kim,DaeKyung;Jankowski,RonJ;Pruchnic,Ryan;Usiene,Irmute;deMiguel,Fernando;Chancellor,MichaelB
我们研究了人肌源性细胞(HMDCs)在裸鼠模型中治疗压力性尿失禁(SUI)的应用。从成人骨骼肌中分离hMDCs。实验动物分为3组，每组6只，分别为对照组、坐骨神经切断加假手术组、坐骨神经切断加hMDCs组(1×106个细胞/20μL生理盐水)。注射后4周测量漏点压力(LPP)。双侧SNT导致LPP显著降低，而HMDCs注射后LPP显著高于假注射。结果表明，单独的人类肌肉细胞疗法在改善SUI动物模型的生理结果方面具有有效性。肌肉神经，2007年
We investigated the use of human muscle‐derived cells (hMDCs) for the treatment of stress urinary incontinence (SUI) in a nude rat model. hMDCs were isolated from adult skeletal muscle. Three groups of six animals consisting of controls, animals undergoing sciatic nerve transection (SNT) with periurethral sham‐injection, and SNT with hMDCs (1 × 106cells/20 μl saline) were utilized. Leak point pressure (LPP) was measured 4 weeks following injection. Bilateral SNT resulted in a significantly lower LPP that was significantly higher following hMDCs than sham injection. The results demonstrate the efficacy of human muscle cell therapy alone in improving physiologic outcomes in an animal model of SUI. Muscle Nerve, 2007