Models of haematopoiesis: seeing the wood for the trees
Models of haematopoiesis: seeing the wood for the trees
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DOI：
10.1038/nri2525
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发表时间：
2009-04-01
影响因子：
100.3
通讯作者：
Brown, Geoffrey
中科院分区：
文献类型：
--
作者：
Ceredig, Rhodri;Rolink, Antonius G.;Brown, Geoffrey
许多造血模型表明造血干细胞在淋巴细胞和骨髓细胞命运之间做出早期和不可撤销的选择。然而，最近的数据表明，中间祖细胞具有淋巴和骨髓潜能，从而反驳了早期的理论，并导致该领域缺乏共识。在这篇观点文章中，我们提出了一个简单的成对关系模型的细胞命运的决定，不依赖于潜在的发展分支点，在其他模型中规定了一个首选的路线（或路线），以特定的细胞命运。
Many models of haematopoiesis dictate that haematopoietic stem cells make an early and irrevocable choice between lymphoid and myeloid cell fates. However, recent data show that intermediate progenitors have both lymphoid and myeloid potential, thereby refuting early theories and leading to a lack of consensus in the field. In this Opinion article we present a simple pairwise relationships model of cell fate determination that does not depend on the underlying developmental branch points that in other models dictate a preferred route (or routes) to a particular cell fate.