A cautionary note on the evaluation of genetic evidence from uniparentally transmitted markers
A cautionary note on the evaluation of genetic evidence from uniparentally transmitted markers
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DOI：
10.1016/j.fsigen.2008.04.001
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发表时间：
2008-09-01
影响因子：
3.1
通讯作者：
Amorim, Antonio
中科院分区：
文献类型：
--
作者：
Amorim, Antonio
将线粒体DNA （mtDNA）和y染色体非同源区等谱系遗传标记的信息与减数重组位点（二倍体/常染色体或单倍体/X染色体）的数据结合成单一似然比是最近提出的一种方法。在这项工作中，我们挑战了这一建议，并证明，虽然从减数分裂时重组的位点获得的遗传证据适用于个体概率计算，但mtDNA和y染色体数据并不适用，因此，将两种标记的证据价值结合起来通常是不一致的，应该避免。必须清楚和明确地说明亲属不参与的假设，必须由法院决定是否接受。2008爱思唯尔爱尔兰有限公司版权所有。
The combination of the information obtained from lineage genetic markers, such as mitochondrial DNA (mtDNA) and the non-homologous region of Y-chromosome, with data resulting from meiotically recombining loci (diploid/autosomal or haplodiploid/X chromosome) into a single likelihood ratio has been recently proposed. In this work we challenge this proposal and demonstrate that while the genetic evidence obtained from loci which reshuffle at meiosis is appropriate for individual probability calculations, mtDNA and Y-chromosome data are not and, consequently, that joining the evidential value of the two types of markers is generally inconsistent and should be avoided. The assumption of non-involvement of relatives must be clearly and explicitly stated and its acceptance must be left to the court decision. (C) 2008 Elsevier Ireland Ltd. All rights reserved.