Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis
Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis
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DOI：
10.1007/s10067-019-04573-7
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发表时间：
2019-10-01
影响因子：
3.4
通讯作者：
Jahanpanah, Parinaz
中科院分区：
文献类型：
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作者：
Enteshari-Moghaddam, Afsaneh;Azami, Ahad;Jahanpanah, Parinaz
膝关节骨关节炎（OA）是一种常见的关节炎，可导致老年人日常活动减少，生活质量下降。重要的是要管理一个适当的治疗，高效率和低副作用。在这项研究中，我们评估了度洛沙丁胺醇和加巴喷丁在中度至重度膝关节OA患者中的疗效。方法150例中重度膝关节骨性关节炎患者随机分为3组：度洛昔单抗30 mg（n = 50）、加巴喷丁300 mg（n = 50）和对乙酰氨基酚1000 mg（n = 50），均每日2次，疗程12周。在干预前、干预后2周、1个月和3个月，采用视觉模拟评分法（VAS）测量疼痛严重程度，采用西安大略和麦克马斯特大学骨关节炎指数（WOMAC）测量功能状态。结果干预后2周、1个月时度洛沙汀组WOMAC总分及各分量表评分均显著低于加巴喷丁组，第3个月末差异无统计学意义。与对乙酰氨基酚组相比，加巴喷丁和度洛沙汀组的疼痛VAS和WOMAC及其子量表的降低幅度均显著更大，组间无显著差异。结论加巴喷丁和度洛沙汀治疗膝关节OA患者3个月后，在减轻疼痛和改善功能状态方面效果相似，可接受。度洛沙汀的作用从第一周开始开始，而加巴喷丁的作用开始逐渐开始，在第三个月结束时最好。
Introduction Knee osteoarthritis (OA) is a common form of arthritis in elders which can lead to reduced daily activity and quality of life. It is important to administer a proper treatment with high efficacy and low side effects. In this study, we evaluated the efficacy of duloxetine and gabapentin in patients with moderate to severe knee OA. Method In this randomized clinical trial, 150 patients with moderate to severe knee OA were randomly allocated to receive duloxetine 30 mg (n = 50), gabapentin 300 mg (n = 50), or acetaminophen 1000 mg (n = 50) all twice a day for 12 weeks. Pain severity using visual analogue scale (VAS) and functional status using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were measured before, 2 weeks, 1 month, and 3 months after intervention. Results WOMAC total and its subscale score were significantly lower in duloxetine compared to gabapentin in 2 weeks and 1 months after intervention, with no significant difference at the end of the third month. Both gabapentin and duloxetine groups had significantly more reduction in pain VAS and WOMAC and its subscales compared to acetaminophen group, with no significant difference between groups. Conclusions Both gabapentin and duloxetine have similar and acceptable effects in pain reduction and improvement of functional status in patients with knee OA at the end of the third month's treatment. Duloxetine effects begin from the first weeks, while gabapentin effects begin gradually with the best at the end of the third month.