Intraocular epiretinal prosthesis to restore vision in blind humans
Intraocular epiretinal prosthesis to restore vision in blind humans
复制标题
眼内视网膜前假体恢复盲人视力
DOI：
10.1109/iembs.2008.4650530
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Peter Walter
中科院分区：
文献类型：
--
作者：
Wilfried Mokwa;M. Goertz;C. Koch;I. Krisch;H. Trieu;Peter Walter
患有视网膜变性的盲人患者的视觉感觉可以通过使用植入式微电极阵列对视网膜神经元进行电刺激来恢复。 EPI-RET-3项目的启动是为了评估人类使用的无线眼内视网膜植入系统的安全性和效率。该植入物是一种远程控制的全眼内假体，由接收器和刺激器模块组成。刺激器被放置在视网膜表面上。数据和能量通过感应链路从眼睛外部传输到植入物。 EPI-RET-3 设备被植入六名患有视网膜色素变性 (RP) 的法定失明患者体内，为期四个星期。手术顺利进行，没有出现并发症。植入物在植入后第7、14和27天被激活。所有患者都报告了不同颜色和强度的视觉感觉，例如点、弧或线。发现所需的刺激阈值非常低。无线 EPI-RET-3 设备的植入是安全的，该系统适合在盲人 RP 患者中引发视觉感觉。这种方法可以解决人工视觉假体设计和制造中的主要问题。
Visual sensations in blind patients suffering from retinal degenerations may be restored by electrical stimulation of retinal neurons using implantable microelectrode arrays. The EPI-RET-3 project was initiated to evaluate a wireless intraocular retinal implant system for human use in terms of safety and efficiency. The implant is a remotely controlled fully intraocular prosthesis consisting of a receiver and a stimulator module. The stimulator is placed onto the retina's surface. Data and energy are transmitted via an inductive link from outside the eye to the implant. The EPI-RET-3 device was implanted into six legally blind patients with Retinitis Pigmentosa (RP) for a period of four weeks. The surgery was performed without complications. The implants were activated on days 7, 14 and 27 after implantation. All patients reported visual sensations such as dots, arcs, or lines of different colours and intensities. The required stimulation thresholds were found to be very low. Implantation of the wireless EPI-RET-3 device is safe and the system is suitable to elicit visual sensations in blind RP patients. Major problems in the design and fabrication of a prosthesis for artificial vision could be solved in this approach.