Behavioral effects of psychomotor stimulants in rats with dorsal or ventral subiculum lesions: Locomotion, cocaine self-administration, and prepulse inhibition of startle
Behavioral effects of psychomotor stimulants in rats with dorsal or ventral subiculum lesions: Locomotion, cocaine self-administration, and prepulse inhibition of startle
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DOI：
10.1037//0735-7044.115.4.880
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发表时间：
2001-08-01
影响因子：
1.9
通讯作者：
Everitt, BJ
中科院分区：
文献类型：
--
作者：
Caine, SB;Humby, T;Everitt, BJ
令人信服的证据表明，中隔伏隔核多巴胺能通路在苯丙胺和可卡因的行为效应中起主要作用。但伏隔核的其他投射，包括那些出现在海马结构中的投射，其作用还不是很清楚。作者评估了背侧或腹侧下丘的离散兴奋性损伤对运动激活的影响。加强和感觉运动门控-精神运动兴奋剂药物的破坏作用。而背侧下丘脑损毁大鼠在探索运动和惊吓反应试验中表现为过度活跃。腹侧下丘脑损毁大鼠表现出对苯丙胺的运动反应减弱，对可卡因自我给药的获得性中度损害，以及对惊厥的脉冲前抑制水平降低。这两种行为特征分别与前人在伏隔背侧和尾内侧损伤大鼠身上观察到的行为特征有相当大的重叠，提示从背侧下丘到伏隔核和腹侧下丘到伏隔壳的投射对精神运动兴奋剂药物放大的行为反应有明显的影响。
Compelling evidence suggests a primary role for the mesoaccumbens dopaminergic pathway in the behavioral effects of amphetamine and cocaine. but the roles of other projections to the accumbens, including those arising in the hippocampal formation, are less clear. The authors evaluated the effects of discrete excitotoxic lesions of either the dorsal or ventral subiculum on the locomotor activating. reinforcing, and sensorimotor gating-disruptive effects of psychomotor stimulant drugs. Whereas dorsal subiculum-lesioned rats were hyperactive in tests of exploratory locomotion and startle reactivity. ventral subiculum-lesioned rats exhibited an attenuated locomotor response to amphetamine, moderately impaired acquisition of cocaine self-administration, and reduced levels of prepulse inhibition of startle. These 2 behavioral profiles overlap considerably with those previously observed in rats with lesions of the rostrodorsal and caudomedial accumbens, respectively, and suggest that projections from dorsal subiculum to accumbens core and ventral subiculum to accumbens shell exert distinct influences on behavioral responses that are amplified by psychomotor stimulant drugs.