Subclinical hypothyroidism [4] (multiple letters)

Subclinical hypothyroidism [4] (multiple letters)
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亚临床甲状腺功能减退症 [4](多个字母)

DOI:
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发表时间:
2001
期刊:
影响因子:
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通讯作者:
David S. Cooper
David S. Cooper
中科院分区:
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文献类型:
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作者:
J. Dashe;Alexander Mazziotti;Martin Press;David S. Cooper

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“亚临床甲状腺功能减退症”一词描述的是血清 TSH 轻微升高且血清游离 T4 和 T3 水平正常的状态,通常没有任何其他甲状腺功能减退症特征的临床表现。这种状态在老年人中相当常见,尤其是女性。亚临床甲状腺功能减退症最常见的是明显甲状腺功能减退症的早期阶段。血清 TSH 轻微升高且甲状腺抗体水平较高的患者每年进展为明显甲状腺功能减退症的比例为 5% 至 20%。亚临床甲状腺功能减退症患者的总胆固醇和高密度脂蛋白胆固醇水平可能升高,虽然不如明显疾病那么明显,但使这些患者容易患上严重的心脏病。因此,有必要考虑对其中一些患者进行左旋甲状腺素治疗,以改善他们的生活质量并防止发展为全面性疾病及其所有后遗症。由于亚临床甲状腺功能减退症在老年人中很常见(60岁以上人群中4%~8%),因此有必要制定基于血清TSH水平测量的筛查政策。
The term ‘subclinical hypothyroidism’ describes the state of slightly elevated serum TSH and normal serum free T4 and T3 levels, usually without any other clinical findings characteristic of hypothyroidism. The state is quite common in the elderly, especially in women. Subclinical hypothyroidism is most commonly an early stage of overt hypothyroidism. Progression to overt hypothyroidism ranges from 5 to 20 percent per year in patients with slightly elevated serum TSH and high thyroid antibody levels. Patients with subclinical hypothyroidism may have increased levels of are total and HDL cholesterol, which are less pronounced than in overt disease but predispose these patients to the development of severe cardiac disease. For this reason, it is necessary to consider levothyroxine therapy in some of these patients, in order to improve their quality of life and to prevent development of full-blown disease with all its sequels. Because subclinical hypothyroidism is common in the elderly (4% 8% of people older than 60), it is necessary to establish a screening policy based on serum TSH level measurement.
DOI: --
发表时间: 1987
期刊: JAMA
影响因子: --
作者:
Rosenthal,MJ;Hunt,WC;Garry,PJ;Goodwin,JS
通讯作者: Goodwin,JS
DOI: 10.1097/00006254-200001000-00002
发表时间: 1999-12
期刊: The New England journal of medicine
影响因子: --
作者:
J. Haddow;G. Palomaki;Walter C. Allan;Josephine Williams;G. Knight;June Gagnon;Cheryl E. O’heir;M. Mitchell;R. Hermos;S. Waisbren;J. Faix;R. Klein
通讯作者: J. Haddow;G. Palomaki;Walter C. Allan;Josephine Williams;G. Knight;June Gagnon;Cheryl E. O’heir;M. Mitchell;R. Hermos;S. Waisbren;J. Faix;R. Klein
在定期健康检查中筛查轻度甲状腺功能衰竭:决策和成本效益分析。
DOI: --
发表时间: 1996
期刊: JAMA : the journal of the American Medical Association
影响因子: --
作者:
Danese,MD;Powe,NR;Sawin,CT;Ladenson,PW
通讯作者: Ladenson,PW
在评估甲状腺状态时使用血清促甲状腺素敏感测定法的局限性。
DOI: --
发表时间: 1989
影响因子: --
作者:
Ehrmann,DA;Weinberg,M;Sarne,DH
通讯作者: Sarne,DH