Allogeneic bone marrow transplantation for juvenile myelomonocytic leukaemia: a single centre experience and review of the literature
Allogeneic bone marrow transplantation for juvenile myelomonocytic leukaemia: a single centre experience and review of the literature
复制标题
异体骨髓移植治疗幼年型粒单核细胞白血病：单中心经验及文献回顾
DOI：
10.1038/sj.bmt.1702522
复制
发表时间：
2000
影响因子：
4.8
通讯作者：
H. Gadner
中科院分区：
文献类型：
--
作者：
S. Matthes‐Martin;G. Mann;C. Peters;T. Lion;G. Fritsch;O. Haas;U. Pötschger;H. Gadner
青少年粒单核细胞白血病（JMML）是一种罕见的儿科疾病，异基因干细胞移植是唯一的治疗方法。移植前治疗、预处理方案和移植物抗宿主病（GVHD）的作用尚不清楚。11例JMML患儿在我院接受了异基因骨髓移植。供者为匹配的非亲缘（n = 6）、匹配的兄弟姐妹（n = 4）和一个错配的家庭供者。移植相关死亡率（TRM）为36%。3例患者移植后复发。三例复发患者中有两例分别在供体淋巴细胞输注或第二次BMT后持续缓解。为了评价移植前治疗、预处理方案和GVHD的作用，我们总结了我们的系列与其他已发表的单中心报告，并对共65例接受同种异体BMT的JMML患者进行了概述。移植前处理、预处理方案与TRM无明显相关性。总体复发率很高（47%）。TBI与显著较高的复发率相关（P = 0.012）。其他预处理方式，强化化疗和脾切除术前干细胞移植似乎没有显着的复发率的影响。有无GVHD患者的复发率无显著差异（58% vs 45%）。如果在移植后复发，停用免疫抑制剂，供体淋巴细胞输注或第二次移植在6/11例患者中获得成功。移植物抗白血病效应在骨髓移植治疗JMML中起重要作用。骨髓移植（2000年）26，377 - 382。
Juvenile myelomonocytic leukaemia (JMML) is a rare paediatric disease and allogeneic stem cell transplantation is the only curative approach. The roles of pretransplant treatment, conditioning regimen and graft-versus-host disease (GVHD) are still unclear. Eleven children with JMML underwent allogeneic BMT in our institution. Donors were matched unrelated (n = 6) matched siblings (n = 4) and one mismatch family donor. Transplant-related mortality (TRM) was 36%. Three patients relapsed after transplantation. Two of three patients with relapse are in continuous remission after donor lymphocyte infusion or second BMT, respectively. To evaluate the role of pretransplant treatment, conditioning regimen and GVHD, we have summarised our series with other published single centre reports and give an overview on a total of 65 patients with JMML who underwent allogeneic BMT. No significant correlation between pretransplant treatment, conditioning regimen and TRM could be observed. Overall relapse rate is high (47%). TBI is associated with a significantly higher relapse rate (P = 0.012). Other conditioning modalities, intensive chemotherapy and splenectomy prior to stem cell transplantation do not seem to have a significant impact on relapse rate. Patients with or without GVHD showed no significant difference in relapse rate (58% vs 45%). In the event of relapse after transplantation withdrawal of immunosuppression, donor lymphocyte infusion or second transplant was successful in 6/11 patients. Graft-versus-leukaemia effect seems to play an essential role in bone marrow transplantation for JMML. Bone Marrow Transplantation (2000) 26, 377–382.
同种异体骨髓移植治疗幼年型慢性粒细胞白血病儿童。
影响因子：
20.3
作者：
Sanders,JE;Buckner,CD;Thomas,ED;Fleischer,R;Sullivan,KM;Appelbaum,FA;Storb,R
通讯作者：
Storb,R
1 型神经纤维瘤病和恶性骨髓疾病儿童的造血谱系受累模式。
影响因子：
20.3
作者：
Miles,DK;Freedman,MH;Stephens,K;Pallavicini,M;Sievers,EL;Weaver,M;Grunberger,T;Thompson,P;Shannon,KM
通讯作者：
Shannon,KM