Mannolides A-C with an Intact Diterpenoid Skeleton Providing Insights on the Biosynthesis of Antitumor Cephalotaxus Troponoids
Mannolides A-C with an Intact Diterpenoid Skeleton Providing Insights on the Biosynthesis of Antitumor Cephalotaxus Troponoids
复制标题
具有完整二萜骨架的甘露内酯 A-C 为抗肿瘤三尖杉 Troponoids 的生物合成提供了见解
DOI：
10.1021/acs.orglett.6b00653
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发表时间：
2016-04-15
期刊：
影响因子：
5.2
通讯作者：
Yue, Jian-Min
中科院分区：
文献类型：
--
作者：
Ni, Gang;Zhang, Hua;Yue, Jian-Min
从曼氏红豆杉中分得三个新的二萜化合物，分别命名为甘露内酯A-C（1-3）和两个新的红豆杉肌钙蛋白化合物4和5。化合物1-3具有一个新的完整的碳骨架，被认为是头孢烷，揭示了新的生物起源的红豆杉troponoids，一类罕见的抗肿瘤C-19降二萜类化合物的发现。抗肿瘤实验表明，酮基序是活性所必需的。
Three new diterpenoids, mannolides A-C (1-3), and two new Cephalotaxus troponoids, 4 and 5, were isolated from Cephalotaxus mannii and structurally characterized by spectroscopic data and X-ray crystallography. The discovery of compounds 1-3 featuring a new intact carbon skeleton, proposed as cephalotane, sheds new light on the biogenesis of Cephalotaxus troponoids, a rare class of antitumor C-19 norditerpenoids. Antitumor tests showed that the tropone motif is essential for the activity.