CD4 αβ T Lymphocytes Express High Levels of the T Lymphocyte Antigen CTLA-4 (CD152) in Acute Malaria
CD4 αβ T Lymphocytes Express High Levels of the T Lymphocyte Antigen CTLA-4 (CD152) in Acute Malaria
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急性疟疾中 CD4 αβ T 淋巴细胞表达高水平的 T 淋巴细胞抗原 CTLA-4 (CD152)
DOI：
10.1086/315690
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
B. Bröker
中科院分区：
文献类型：
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作者：
T. Schlotmann;I. Waase;C. Jülch;U. Klauenberg;B. Müller;M. Dietrich;B. Fleischer;B. Bröker
T淋巴细胞在人类急性疟疾中的作用仍有争议。研究了急性疟疾中T细胞活化的动力学，重点是CTLA-4（CD 152）。在疟疾患者中，CD 4 ab T淋巴细胞的CTLA-4表达高度增加。在开始抗疟原虫治疗后，它在几天内恢复到对照值。gd T细胞也与人疟疾的发病机制有关，不表达CTLA-4。入院时CTLA-4表达水平与疾病严重程度的其他标志物-寄生虫血症峰值和血清新蝶呤水平峰值呈正相关。提示CTLA-4是一种敏感的、动态的T淋巴细胞活化标志物。它在急性疟疾中的强烈增加证明了T细胞参与了人类对疟原虫的免疫反应。在实验性啮齿动物疟疾中，T淋巴细胞对于寄生虫清除是必不可少的，但同时也有助于致命并发症的发病机制，如脑型疟疾[1]。T淋巴细胞在人类急性疟疾中的作用目前正处于激烈的争论中[2，3]。我们研究了急性疟疾中T细胞活化的动力学，重点是CTLA-4（CD 152）的表达。CTLA-4与共刺激表面分子CD 28具有同源性，并且两者都结合抗原呈递细胞CD 80和CD 86上的相同配体。与CD 28相反，CTLA-4仅在活化后在T细胞上表达。然后，该分子通过抑制T细胞应答并确保外周免疫耐受来实现基本的抑制功能[4]。CTLA-4的检测
The role of T lymphocytes in human acute malaria remains under debate. The kinetics of T cell activation in acute malaria were investigated, with emphasis on CTLA-4 (CD152). In patients with malaria, CTLA-4 expression by CD4 ab T lymphocytes was highly increased. After initiation of antiplasmodial treatment, it returned to control values within a few days. gd T cells, which also are implicated in the pathogenesis of human malaria, did not express CTLA-4. The level of CTLA-4 expression at the time of hospital admission was correlated positively with other markers of disease severity—the peak of the parasitemia and the peak of serum neopterin levels. These results show that CTLA-4 is a sensitive and dynamic marker for T lymphocyte activation. Its strong increase in acute malaria argues for the involvement of T cells in the human immune response to plasmodia. In experimental rodent malaria, T lymphocytes are indispensable for parasite clearance but, at the same time, contribute to the pathogenesis of lethal complications, such as cerebral malaria [1]. The role of T lymphocytes in human acute malaria is currently under intense debate [2, 3]. We investigated the kinetics of T cell activation in acute malaria, with emphasis on the expression of CTLA-4 (CD152). CTLA-4 shares homology with the costimulatory surface molecule CD28, and both bind to the same ligands on antigen-presenting cells CD80 and CD86. In contrast to CD28, CTLA-4 is expressed on T cells only after activation. Then the molecule fulfills an essential inhibitory function by dampening the T cell response and ensuring peripheral immunotolerance [4]. Detection of CTLA-4