Calcium channels blocked activity: Providing the basis for medicinal use of Abies pindrow in diarrhea and bronchitis
Calcium channels blocked activity: Providing the basis for medicinal use of Abies pindrow in diarrhea and bronchitis
复制标题
钙通道活性受阻：为冷杉治疗腹泻和支气管炎的药用提供基础
DOI：
10.3329/bjp.v10i2.22246
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Hafiz Muhammad Abdur Rahman
中科院分区：
文献类型：
--
作者：
S. Mushtaq;M. A. Chaudhry;Hafiz Muhammad Abdur Rahman
冷杉粉被广泛用于治疗腹泻和支气管炎的传统做法，本研究旨在验证其民俗用途。采用粗提物法提取A. pindrow以浓度依赖性方式抑制自发收缩（1-10 mg/mL）和高K +（80 mM）诱导的预收缩（3 mg/mL）。在粗提物（0.1-0.3）的存在下，观察到Ca +2浓度响应曲线的显著偏移，与维拉帕米相似。在离体气管组织中，A. pindrow分别在3 mg/mL和10 mg/mL浓度下抑制高K +和卡巴胆碱（1 µM）诱导的收缩，与维拉帕米引起的收缩相似。这些结果表明，在粗提物中存在钙通道阻断活性。pindrow，为A.腹泻和支气管炎的副作用
Abies pindrow is widely used in traditional practice for the treatment of diarrhea and bronchitis and the present study was designed to validate its folkloric uses. The crude extract of A. pindrow inhibit spontaneously contracting (1-10 mg/mL) and high K + (80 mM)-induced pre-contracted rabbit jejun-um (3 mg/mL) in concentration dependent manner. A rightward shift in Ca +2 concentration response curves was seen in the presence of crude extract (0.1-0.3), similar to verapamil. In isolated tracheal tissue, A. pindrow inhibited, high K + and carbachol (1 µM)-induced contractions, at 3 mg/mL and 10 mg/mL respectively, similar to that caused by verapamil. These results indicate the presence of calcium channels blocked activity in crude extract of A. pindrow , which provide sound basis for medicinal uses of A. pindrow in diarrhea and bronchitis.