Development and Characterization of a Tissue-Mimicking Material for High-Intensity Focused Ultrasound
Development and Characterization of a Tissue-Mimicking Material for High-Intensity Focused Ultrasound
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DOI：
10.1109/tuffc.2011.1959
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发表时间：
2011-07-01
影响因子：
3.6
通讯作者：
Harris, Gerald R.
中科院分区：
文献类型：
--
作者：
King, Randy L.;Liu, Yunbo;Harris, Gerald R.
研制了一种用于高强度聚焦超声(HIFU)装置声学和热特性研究的仿组织材料(TMM)。该材料是一种高温水凝胶基质(结冷胶)，由不同大小的氧化铝颗粒和其他化学品组合而成。超声性能(衰减系数、声速、声阻抗、导热系数和扩散系数)在20~70℃范围内随温度变化而变化。在室温下测量了后向散射系数和非线性参数B/A。重要的是，衰减系数基本上与频率呈线性关系，就像大多数哺乳动物组织在37℃时的情况一样。根据从2到8 MHz的测量结果，在20℃时的平均值为0.64f(0.95)dB.cm(-1)。大多数其他相关物理参数也接近报告值，尽管与典型的人体软组织相比，后向散射信号较低。在20-S高强度聚焦超声照射下，在TMM中产生了40摄氏度的可重复和一致的温度升高。这种TMM适用于发展标准化的剂量学技术，验证数值模型，以及确定HIFU设备的安全性和有效性。
A tissue-mimicking material (TMM) for the acoustic and thermal characterization of high-intensity focused ultrasound (HIFU) devices has been developed. The material is a high-temperature hydrogel matrix (gellan gum) combined with different sizes of aluminum oxide particles and other chemicals. The ultrasonic properties (attenuation coefficient, speed of sound, acoustical impedance, and the thermal conductivity and diffusivity) were characterized as a function of temperature from 20 to 70 degrees C. The backscatter coefficient and nonlinearity parameter B/A were measured at room temperature. Importantly, the attenuation coefficient has essentially linear frequency dependence, as is the case for most mammalian tissues at 37 degrees C. The mean value is 0.64f (0.95) dB.cm(-1) at 20 degrees C, based on measurements from 2 to 8 MHz. Most of the other relevant physical parameters are also close to the reported values, although backscatter signals are low compared with typical human soft tissues. Repeatable and consistent temperature elevations of 40 degrees C were produced under 20-s HIFU exposures in the TMM. This TMM is appropriate for developing standardized dosimetry techniques, validating numerical models, and determining the safety and efficacy of HIFU devices.