Reliability of tumour grade 1 and endometrioid cell type on preoperative endometrial biopsy
Reliability of tumour grade 1 and endometrioid cell type on preoperative endometrial biopsy
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术前子宫内膜活检中肿瘤 1 级和子宫内膜样细胞类型的可靠性
DOI：
10.3109/01443615.2014.935723
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发表时间：
2015
影响因子：
1.3
通讯作者：
J. Nam
中科院分区：
文献类型：
--
作者：
M. Baek;Y.R. Park;D. Suh;S. Lee;J. Park;D. Kim;J. Kim;Y. Kim;Y. Kim;J. Nam
摘要 本研究的目的是评估术前子宫内膜活检中使用肿瘤分级和细胞类型来选择保守激素治疗患者的可靠性。我们回顾性分析了 643 例子宫内膜癌患者的肿瘤分级和 817 例肿瘤细胞类型的结果，这些患者接受了子宫内膜活检并随后进行了手术。在 357 名术前子宫内膜活检发现 1 级肿瘤的患者中，58 名 (16.2%) 根据子宫切除标本的最终病理报告进行了升级。对于1级，术前子宫内膜活检的敏感性为80.4%，特异性为78.6%，阳性预测值（PPV）为83.8%，阴性预测值（NPV）为74.5%。在 672 名术前活检为子宫内膜样细胞类型的患者中，46 名 (5.6%) 在最终病理学中显示出不同的细胞类型。对于子宫内膜样细胞类型，术前子宫内膜活检的敏感性为91.3%，特异性为64.9%，PPV为93.2%，NPV为58.6%。在选择患者进行保守激素治疗时，应考虑这种弱预测值。
Abstract The aim of this study was to evaluate the reliability of using tumour grade and cell type on preoperative endometrial biopsy for the selection of patients for conservative hormone treatment. We retrospectively reviewed results of 643 patients with endometrial carcinoma for tumour grade and 817 for tumour cell type who underwent endometrial biopsy followed by surgery. Of the 357 patients with a grade 1 tumour on preoperative endometrial biopsy, 58 (16.2%) were upgraded based on a final pathology report from hysterectomy specimens. For grade 1, the preoperative endometrial biopsy showed a sensitivity of 80.4%, a specificity of 78.6%, a positive predictive value (PPV) of 83.8% and a negative predictive value (NPV) of 74.5%. Of the 672 patients with the endometrioid cell type on preoperative biopsy, 46 (5.6%) showed a different cell type on final pathology. For the endometrioid cell type, preoperative endometrial biopsy had a sensitivity of 91.3%, a specificity of 64.9%, a PPV of 93.2% and an NPV of 58.6%. This weak predictive value should be considered when selecting patients for conservative hormone treatment.
影响因子：
6.1
作者：
Yamazawa, Koji;Hirai, Makiko;Isaka, Keiichi
通讯作者：
Isaka, Keiichi