Exercise as a potential treatment for drug abuse: evidence from preclinical studies.
Exercise as a potential treatment for drug abuse: evidence from preclinical studies.
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DOI：
10.3389/fpsyt.2011.00082
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发表时间：
2011
影响因子：
4.7
通讯作者：
Lynch WJ
中科院分区：
文献类型：
--
作者：
Smith MA;Lynch WJ
流行病学研究表明，经常进行有氧运动的人使用和滥用非法药物的可能性较小。直到最近，很少有研究探讨了调解这种关系的因果影响，也不清楚运动是否能有效减少药物使用和滥用。在过去的几年里，一些临床前研究表明，运动减少了实验室动物的自我给药。这些研究表明，运动在设计用于模拟物质使用障碍（例如，药物使用的获得、维持、升级和复发/恢复）。此外，最近的研究揭示了运动的几种行为和神经生物学后果，这些后果可能是运动在这些测定中的保护作用的原因。总的来说，这些研究提供了令人信服的证据，支持开发基于运动的干预措施，以减少临床和高危人群的药物摄入强迫模式。
Epidemiological studies reveal that individuals who engage in regular aerobic exercise are less likely to use and abuse illicit drugs. Until recently, very few studies had examined the causal influences that mediate this relationship, and it was not clear whether exercise was effective at reducing substance use and abuse. In the past few years, several preclinical studies have revealed that exercise reduces drug self-administration in laboratory animals. These studies have revealed that exercise produces protective effects in procedures designed to model different transitional phases that occur during the development of, and recover from, a substance use disorder (e.g., acquisition, maintenance, escalation, and relapse/reinstatement of drug use). Moreover, recent studies have revealed several behavioral and neurobiological consequences of exercise that may be responsible for its protective effects in these assays. Collectively, these studies have provided convincing evidence to support the development of exercise-based interventions to reduce compulsive patterns of drug intake in clinical and at-risk populations.