Dietary habits and nutrient intake in non-alcoholic steatohepatitis
Dietary habits and nutrient intake in non-alcoholic steatohepatitis
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DOI：
10.1016/j.nut.2006.09.004
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发表时间：
2007-01-01
期刊：
影响因子：
4.4
通讯作者：
Onji, Morikazu
中科院分区：
文献类型：
--
作者：
Toshimitsu, Kumiko;Matsuura, Bunzo;Onji, Morikazu
目的：非酒精性脂肪性肝炎（NASH）是最重要的新兴健康问题之一。胰岛素抵抗和代谢综合征在NASH的发病机制中起核心作用。营养物质的摄入强烈影响胰岛素抵抗、碳水化合物和脂质代谢以及肝脏脂肪变性。然而，关于非酒精性脂肪性肝病中各种营养素摄入的报道很少。在这项工作中，我们确定了NASH患者的饮食习惯和营养摄入特征。方法：对28例NASH患者和18例单纯性脂肪变性（FL）患者进行组织学诊断，通过医师和营养师的详细询问，分析其饮食习惯和营养物质摄入情况。结果：与FL患者相比，20-59岁NASH患者的碳水化合物/能量摄入过量。在碳水化合物中，NASH患者的简单碳水化合物摄入量较高。与脂肪肝患者相比，40-59岁NASH患者的蛋白质/能量摄入量较低，20-59岁NASH患者的锌摄入量较低。与一般日本受试者相比，NASH患者和脂肪肝患者的多不饱和脂肪酸与饱和脂肪酸的摄入比例较低。结论：不平衡饮食对幼鼠的发育发育起重要作用。在NASH患者中，可能有必要纠正这些饮食。(c) 2007爱思唯尔公司版权所有。
Objective: Non-alcoholic steatohepatitis (NASH) is one of the most important emerging health issues. Insulin resistance and metabolic syndrome play a central role in the pathogenesis of NASH. Intake of nutrients strongly affects insulin resistance, carbohydrate and lipid metabolism, and hepatic steatosis. However, there are few reports about the intake of various nutrients in nonalcoholic fatty liver disease. In this work, we identified the characteristics of dietary habits and nutrient intake in patients with NASH.Methods: Twenty-eight patients with NASH and 18 with simple steatosis (FL) were diagnosed from histologic findings, and their dietary habits and intake of nutrients were analyzed by detailed questioning by physicians and dieticians.Results: There was an excess intake of carbohydrates/energy in patients with NASH 20-59 y of age compared with patients with FL. Among carbohydrates, intake of simple carbohydrates was higher in those with NASH. There also was a low intake of protein/energy in patients with NASH 40-59 y of age and a low intake of zinc in those 20-59 y of age compared with patients with FL. Ratio of intake of polyunsaturated fatty acid to saturated fatty acid was lower in patients with NASH and those with FL compared with the general Japanese subjects.Conclusion: These results suggest that imbalanced diets play important roles in development and progression. of NASH and correction of these diets may be necessary in patients with NASH. (c) 2007 Elsevier Inc. All rights reserved.