Cardiac Reprogramming: Toward a Total Eclipse of the Failing Heart.
Cardiac Reprogramming: Toward a Total Eclipse of the Failing Heart.
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心脏重新编程：走向衰竭心脏的彻底消失。
DOI：
10.1161/circulationaha.122.062691
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发表时间：
2023
期刊：
影响因子：
37.8
通讯作者：
Olson,EricN
中科院分区：
文献类型：
--
作者：
Garry,GlynnisA;Olson,EricN
在美国和全世界，由缺血性心脏病引起的心力衰竭是导致死亡、发病率和医疗保健支出的主要原因。心力衰竭确诊时的死亡率是惊人的；在5年内，50%的患者将死亡。1尽管取得了进展，但死亡率略有改善，治疗心力衰竭的唯一方法仍然是移植。在美国，每年进行的移植手术不到4000例。超过20万名患者被列为有资格接受心脏移植，还有数百万人在没有被列入名单的情况下死亡。因此，迫切需要治疗心力衰竭的新疗法。为了达到这一目标，在最新一期的《循环》中，Tani等人报道了心脏重新编程对慢性缺血性心力衰竭的治疗效果。3通过优雅的活体概念验证研究，这项工作预示着重新编程的未来前景广阔，并有望成为一个热切期待将科学驱动的创新转化为心力衰竭疗法的领域。
Heart failure resulting from ischemic heart disease is the leading cause of death, morbidity, and health care expenditure in the United States and worldwide. Mortality from the time of diagnosis of heart failure is staggering; within 5 years, 50% of patients will have died. 1 Despite advances, mortality rates have improved modestly, and the only cure for heart failure remains transplantation. Fewer than 4000 transplantations are performed in the United States annually. More than 200 000 patients are listed as eligible for heart transplantation, and millions more die without listing. 2 Thus, novel therapies for heart failure are desperately needed. Toward this goal, in the current issue of Circulation, Tani et al report the therapeutic efficacy of cardiac reprogramming for chronic ischemic heart failure. 3 Through elegant in vivo proof-of-concept studies, this work signals great promise for the future of reprogramming and hope for a field eagerly awaiting translation of science-driven innovations to heart failure therapies.