The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases.
The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases.
复制标题
Lipocalin-2/ngal作为炎症和代谢疾病的生物标志物的潜力。
DOI：
10.3109/1354750x.2015.1123354
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Gualillo O
中科院分区：
文献类型：
--
作者：
Abella V;Scotece M;Conde J;Gómez R;Lois A;Pino J;Gómez-Reino JJ;Lago F;Mobasheri A;Gualillo O
脂载蛋白-2 (LCN2)，也称为中性粒细胞明胶酶相关脂载蛋白（NGAL），是一种分泌的糖蛋白，属于循环中的一组亲脂小分子转运体。LCN2最近被认为是一种脂肪来源的细胞因子。这种脂肪因子被认为可以结合小物质，如类固醇和脂多糖，并在诱导造血细胞凋亡、脂肪酸和铁的运输、炎症调节和代谢稳态中发挥作用。最近，LCN2已成为风湿病的有用生物标志物。本文综述了LCN2在炎症、免疫和代谢中的作用。
Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to bind small substances, such as steroids and lipopolysaccharides, and has been reported to have roles in the induction of apoptosis in hematopoietic cells, transport of fatty acids and iron, modulation of inflammation, and metabolic homeostasis. Recently, LCN2 has emerged as a useful biomarker and rheumatic diseases. This review provides an overview of LCN2 in inflammation, immunity, and metabolism.