Stability of Tetrahydrocannabinol and Cannabidiol in Prepared Quality Control Medible Brownies.
Stability of Tetrahydrocannabinol and Cannabidiol in Prepared Quality Control Medible Brownies.
复制标题
四氢大麻酚和大麻二酚在制备的质量控制食用布朗尼中的稳定性。
DOI：
10.1093/jat/bkw114
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发表时间：
2017
影响因子：
2.5
通讯作者：
Poklis,Alphonse
中科院分区：
文献类型：
--
作者：
Wolf,CarlE;Poklis,JustinL;Poklis,Alphonse
在过去的几年里，大麻在美国的药用和娱乐用途的合法化有所增加。目前，有24个州将大麻合法化用于医疗用途。美国缉毒局已将大麻列为附表I物质。美国食品和药物管理局不监管目前在大麻合法化的州销售的大麻制剂或包装。大麻食品或“medibles”通常是用于药用和娱乐大麻使用的糖果和烘焙食品的包装。它们含有大麻中的主要精神活性药物，delta-9-tetrahydrocannabinol（THC）和/或cannabidiol（CBD），具有良好的医疗特性。本发明提供了一种用于制备和应用含有THC和CBD的布朗尼的方法，所述布朗尼用作用于分析大麻或大麻素烘焙中碎料的质量控制（QC）材料。提供了测定的性能参数，包括可能的基质效应和布朗尼QC中大麻素随时间的稳定性。确定用于制备和烘焙布朗尼对照材料的方法不会降解THC或CBD。发现布朗尼基质不干扰THC或CBD的分析。评估了10种市售布朗尼基质的潜在干扰;没有发现它们干扰THC或CBD的分析。实验室烘焙的medible QC材料在室温下可稳定至少3个月。
The legalization of marijuana in the USA for both medicinal and recreational use has increased in the past few years. Currently, 24 states have legalized marijuana for medicinal use. The US Drug Enforcement Administration has classified marijuana as a Schedule I substance. The US Food and Drug Administration does not regulate formulations or packages of marijuana that are currently marketed in states that have legalized marijuana. Marijuana edibles or “medibles” are typically packages of candies and baked goods consumed for medicinal as well as recreational marijuana use. They contain major psychoactive drug in marijuana, delta-9-tetrahydrocannabinol (THC) and/or cannabidiol (CBD), which has reputed medical properties. Presented is a method for the preparation and application of THC and CBD containing brownies used as quality control (QC) material for the analysis of marijuana or cannabinoid baked medibles. The performance parameters of the assay including possible matrix effects and cannabinoid stability in the brownie QC over time are presented. It was determined that the process used to prepare and bake the brownie control material did not degrade the THC or CBD. The brownie matrix was found not to interfere with the analysis of a THC or a CBD. Ten commercially available brownie matrixes were evaluated for potential interferences; none of them were found to interfere with the analysis of THC or CBD. The laboratory baked medible QC material was found to be stable at room temperature for at least 3 months.