Stem cells in the spleen: Therapeutic potential for Sjogren's syndrome, type I diabetes, and other disorders
Stem cells in the spleen: Therapeutic potential for Sjogren's syndrome, type I diabetes, and other disorders
复制标题
DOI：
10.1016/j.biocel.2010.06.012
复制
发表时间：
2010-10-01
影响因子：
4
通讯作者：
Davis, Miriam
中科院分区：
文献类型：
--
作者：
Faustman, Denise L.;Davis, Miriam
认为脾是一个不必要的器官的观点已经被打破。证据表明，脾是自然产生的多潜能干细胞的来源，可能具有多潜能。干细胞不仅隔离在动物的脾中，也隔离在正常成人的脾中。细胞库是为分化而设置的，在自体或异体使用之前，它们不需要在体外或体外进行操作。Hox11谱系的脾干细胞在疾病或损伤中被发现分化为胰岛、唾液上皮细胞和成骨细胞样细胞、脑神经元、耳蜗、淋巴细胞和更分化的免疫细胞，用于修复受损的心脏细胞。靶组织的损伤或疾病会诱导这些仍在脾中的干细胞上调同样的胚胎转录因子，这些转录因子被人工引入诱导的多能干细胞(IPS)。脾干细胞可能具有广泛的多潜能，但与iPS细胞不同的是，它具有较低的致癌风险。(C)2010爱思唯尔有限公司。保留所有权利。
The view of the spleen as an unnecessary organ has been shattered. The evidence shows the spleen to be a source of naturally-occurring multipotent stem cells with possibly pluripotent potential. The stem cells are sequestered in the spleen of not only of animals but also of normal human adults. The reservoir of cells is set for differentiation and they need not be manipulated in vitro or ex vivo before autologous or heterologous use. Splenic stem cells, of Hox11 lineage, have been found in disease or injury to differentiate into pancreatic islets, salivary epithelial cells and osteoblast-like cells, cranial neurons, cochlea, lymphocytes, and more differentiated immune cells that repair injured heart cells. Injury or disease in target tissues induces these stem cells, still in the spleen, to upregulate the same embryonic transcription factors artificially introduced into induced pluripotent stem cells (iPS). Splenic stem cells may have broad pluripotent potential, but unlike iPS cells, possess low oncogenic risk. (c) 2010 Elsevier Ltd. All rights reserved.