Neuroprotective effects of the inhalational anesthetics isoflurane and xenon after cardiac arrest in pigs
Neuroprotective effects of the inhalational anesthetics isoflurane and xenon after cardiac arrest in pigs
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DOI：
10.1097/ccm.0b013e31818a904a
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发表时间：
2008-11-01
影响因子：
8.8
通讯作者：
Fries, Michael
中科院分区：
文献类型：
--
作者：
Derwall, Matthias;Timper, Anne;Fries, Michael
目的：心脏骤停心肺复苏后的神经学结果预后不良，改善脑损伤的治疗选择有限。设计：两项研究氙（Xe）和异氟醚（Iso）在长时间心脏骤停和随后的心肺复苏的猪模型中对功能性神经学结果影响的方案的报告。设置：前瞻性，随机化，实验室动物研究。受试者：雄性家猪（野猪）.干预措施：在心脏骤停8分钟和心肺复苏5分钟成功复苏后，心肺复苏后1小时，将猪随机接受Xe 1或5小时，与未处理的对照组相比（方案1）或接受Iso或Iso，与心肺复苏后10分钟未处理的对照组相比测量和主要结果：将动物暴露于已建立的认知功能测试，并使用神经功能缺损评分评估总体神经功能表现。在协议1中，ESTA管理导致早期认知和整体神经功能的改善，而在协议2中有功能performance.Conclusions没有显着的影响：虽然ESTA赋予功能性神经功能的改善，即使当治疗延迟1小时，早期治疗ESTA或ISO翻译到只有边际功能改善。(Crit Care Med 2008; 36[Suppl.]：S492-S495）
Objective: Neurologic outcome after cardiopulmonary resuscitation from cardiac arrest carries a poor prognosis and treatment options to ameliorate brain damage are limited.Design: Report of two protocols investigating the effects of xenon (Xe) and isoflurane (Iso) in a porcine model of prolonged cardiac arrest and subsequent cardiopulmonary resuscitation on functional neurologic outcomes.Setting: Prospective, randomized, laboratory animal study.Subjects: Male domestic pigs (Sus scrofa).Interventions: After successful resuscitation from 8 mins of cardiac arrest and 5 mins of cardiopulmonary resuscitation, pigs were randomized to receive either Xe for 1 or 5 hrs in comparison with untreated controls 1 hr after cardiopulmonary resuscitation (protocol 1) or to receive Iso or Xe in comparison with untreated controls 10 mins after cardiopulmonary resuscitation (protocol 2).Measurements and Main Results: Animals were exposed to an established cognitive function test and gross neurologic performance was assessed using a neurologic deficit score. In protocol 1, Xe administration resulted in improved early cognitive and overall neurologic function, whereas in protocol 2 there was no significant effect on functional performance.Conclusions: Although Xe conferred functional neurologic improvement even when treatment was delayed for 1 hr, the early treatment with either Xe or Iso translated to only marginal functional improvement. (Crit Care Med 2008; 36[Suppl.]:S492-S495)