Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses
Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses
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DOI：
10.1016/s0092-8674(00)80693-5
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发表时间：
2000-03-03
期刊：
影响因子：
64.5
通讯作者：
Figdor, CG
中科院分区：
文献类型：
--
作者：
Geijtenbeek, TBH;Torensma, R;Figdor, CG
树突状细胞(DC)和静息T细胞之间的接触是启动初级免疫反应所必需的。在这里，我们证明了由静息T细胞表达的ICAM-3在与DC的第一次接触中是重要的。我们发现，一种新的DC特异性C型凝集素DC-SIGN与ICAM-3高亲和力结合，而不是常见的ICAM-3受体LFA-1和αDβ2。DC-SIGN在体外和体内均有大量表达，可介导与T细胞的瞬时黏附。由于DC-SIGN抗体抑制DC诱导的静息T细胞增殖，我们的发现预测DC-SIGN通过稳定DC-T细胞接触区而使T细胞受体结合。
Contact between dendritic cells (DC) and resting T cells is essential to initiate a primary immune response. Here, we demonstrate that ICAM-3 expressed by resting T cells is important in this first contact with DC. We discovered that instead of the common ICAM-3 receptors LFA-1 and alpha D beta 2, a novel DC-specific C-type lectin, DC-SIGN, binds ICAM-3 with high affinity. DC-SIGN, which is abundantly expressed by DC both in vitro and in vivo, mediates transient adhesion with T cells. Since antibodies against DC-SIGN inhibit DC-induced proliferation of resting T cells, our findings predict that DC-SIGN enables T cell receptor engagement by stabilization of the DC-T cell contact zone.