The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017
The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017
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DOI：
10.1016/s1473-3099(19)30418-9
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发表时间：
2019-12-01
影响因子：
56.3
通讯作者：
Crump, John A.
中科院分区：
文献类型：
--
作者：
Stanaway, Jeffrey D.;Parisi, Andrea;Crump, John A.
背景非伤寒沙门氏菌侵袭性疾病是全球发病率和死亡率的主要原因。营养不良的儿童、最近患疟疾或镰状细胞贫血的儿童以及感染艾滋病毒的成年人患病的风险特别高。我们试图估计2017年全球疾病负担、伤害和风险因素研究（GBD）中归因于非伤寒性Salmonella侵袭性疾病的疾病负担。方法我们对科学数据库和灰色文献进行了系统回顾，并估计了1990年至2017年非伤寒性Salmonella侵袭性疾病的发病率和死亡率，按年龄、性别、和地理位置使用DisMod-MR，贝叶斯元回归工具。我们通过年龄、HIV感染状况和社会人口学发展来估计病死率。我们还计算了艾滋病毒可归因分数和估计的健康差距指标，包括残疾调整生命年（DADs）。（95%不确定区间409000 - 705000）2017年发生非伤寒沙门氏菌侵袭性疾病病例，撒哈拉以南非洲地区发病率最高（34.5 [26.6-45.0]例/100 000人年），5岁以下儿童发病率最高（34.3 [23.2-54.7]例/100 000人年）。2017年估计有77500人（46400 - 123000人）死亡，其中18400人（12000 - 27700人）死于艾滋病毒。其余59100例（33300 - 98100）非艾滋病毒死亡占2017年426万（238 - 738）丹麦克朗。所有年龄组的平均病死率为14.5%（9.2-21.1），5岁以下儿童的估计数较高（13.5% [8.4-19.8]）和老年人（51.2% [30.2-72.9]在≥ 70岁的人中），艾滋病毒感染者（41.8% [30.0-54.0]），以及社会人口发展水平较低的地区（例如，撒哈拉以南非洲地区为15.8% [10.0-22.9]）。解释我们提供了作为2017年全球生物多样性报告一部分的非伤寒沙门氏菌侵袭性疾病的首次全球估计值。由于疾病负担很高，特别是在儿童、老年人和艾滋病毒感染者中，调查非伤寒沙门氏菌入侵性疾病的来源和传播途径对于实施有效的预防和控制措施至关重要。版权所有（c）2019作者。由Elsevier Ltd.出版。这是一篇开放获取文章，使用CC BY 4.0许可证。
Background Non-typhoidal salmonella invasive disease is a major cause of global morbidity and mortality. Malnourished children, those with recent malaria or sickle-cell anaemia, and adults with HIV infection are at particularly high risk of disease. We sought to estimate the burden of disease attributable to non-typhoidal salmonella invasive disease for the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017.Methods We did a systematic review of scientific databases and grey literature, and estimated non-typhoidal salmonella invasive disease incidence and mortality for the years 1990 to 2017, by age, sex, and geographical location using DisMod-MR, a Bayesian meta-regression tool. We estimated case fatality by age, HIV status, and sociodemographic development. We also calculated the HIV-attributable fraction and estimated health gap metrics, including disability-adjusted life-years (DALYs).Findings We estimated that 535 000 (95% uncertainty interval 409 000-705 000) cases of non-typhoidal salmonella invasive disease occurred in 2017, with the highest incidence in sub-Saharan Africa (34.5 [26.6-45.0] cases per 100 000 person-years) and in children younger than 5 years (34.3 [23.2-54.7] cases per 100 000 person-years). 77 500 (46 400-123 000) deaths were estimated in 2017, of which 18 400 (12 000-27 700) were attributable to HIV. The remaining 59 100 (33 300-98 100) deaths not attributable to HIV accounted for 4.26 million (2.38-7.38) DALYs in 2017. Mean all-age case fatality was 14.5% (9.2-21.1), with higher estimates among children younger than 5 years (13.5% [8.4-19.8]) and elderly people (51.2% [30.2-72.9] among those aged >= 70 years), people with HIV infection (41.8% [30.0-54.0]), and in areas of low sociodemographic development (eg, 15.8% [10.0-22.9] in sub-Saharan Africa).Interpretation We present the first global estimates of non-typhoidal salmonella invasive disease that have been produced as part of GBD 2017. Given the high disease burden, particularly in children, elderly people, and people with HIV infection, investigating the sources and transmission pathways of non-typhoidal salmonella invasive disease is crucial to implement effective preventive and control measures.Funding Bill & Melinda Gates Foundation. Copyright (c) 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.