Cyclophane-based tetra(resorcinarene) as a host for both histone and hydrophobic molecular guests
Cyclophane-based tetra(resorcinarene) as a host for both histone and hydrophobic molecular guests
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DOI：
10.1016/j.tetlet.2006.03.170
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发表时间：
2006-06-06
影响因子：
1.8
通讯作者：
Uchiyama, Masaki
中科院分区：
文献类型：
--
作者：
Hayashida, Osamu;Uchiyama, Masaki
合成了一个四氮杂[6.1.6.1]对环芳烃和四个含有七(羧酸)残基的间苯二酚四聚体，它们通过酰胺键连接到大环上。用表面等离子体共振法测得环芳烃与固定化组蛋白的结合常数为1.3×10(7)M-1，比含八酸的间苯二酚单体的结合常数大31倍。此外，基于环芳基的四(间苯二酚)作为疏水分子客体的宿主，如6-对甲苯基萘-2-磺酸盐。(C)2006爱思唯尔有限公司。保留所有权利。
A cyclophane-based resorcinarene tetramer, which is constructed with a tetraaza[6.1.6.1]paracyclophane and four resorcinarenes bearing hepta(carboxylic acid) residues that connect the macrocycle through amide linkages, was prepared. The binding constant of the cyclophane-based resorcinarene with immobilized histone was determined to be 1.3 x 10(7) M-1 by surface plasmon resonance measurements, which was 31-fold larger than that of the resorcinarene monomer bearing octacarboxylic acids. Moreover, the cyclophane-based tetra(resorcinarene) acted as a host toward hydrophobic molecular guests such as 6-p-toluidinonaphthalene-2-sulfonate. (c) 2006 Elsevier Ltd. All rights reserved.