Interleukin-1beta and interferon-gamma induce proliferation and apoptosis in cultured Schwann cells
Interleukin-1beta and interferon-gamma induce proliferation and apoptosis in cultured Schwann cells
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DOI：
10.1016/s0165-5728(02)00003-6
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发表时间：
2002-03-01
影响因子：
3.3
通讯作者：
Scarlato, G
中科院分区：
文献类型：
--
作者：
Conti, G;De Pol, A;Scarlato, G
本研究报告了在雪旺细胞组织培养中，两种促炎细胞因子--白介素1-β(IL-1β)和干扰素-γ(干扰素-γ)在不同剂量下单独或联合应用可诱导细胞凋亡和/或有丝分裂。50U/mlIFN-γ作用24 h后雪旺细胞凋亡率最高，10 U/mlIL-1β作用24 h后细胞增殖达高峰，48 h和72 h后两个过程均呈递减趋势，且两种细胞因子联合作用未见协同作用。这些数据可以被解释为促炎细胞因子可能不仅参与了髓鞘破坏，也参与了促进髓鞘再生。(C)2002 Elsevier Science B.V.保留所有权利。
This study reports that in Schwann cell tissue culture the administration of the two pro-inflammatory cytokines, interleukin-1 beta (IL-1beta) and interferon-gamma (IFN-gamma), at different dosages, singly or in combination, can induce apoptosis and/or mitosis. Schwann cell apoptosis was maximal within 24 h of stimulation with 50 U/ml of IFN-gamma, while proliferation was at its peak within 24 h with 10 U/ml IL-1beta, and both processes decreased progressively by 48 and 72 h. Moreover, the combination of the two cytokines did not show any synergistic effect. These data can be interpreted as a possible involvement of pro-inflammatory cytokines not only in myelin disruption but also in promoting remyelination. (C) 2002 Elsevier Science B.V. All rights reserved.